Aqp2Cre Pkd2(f/f) (Pkd2(AC)) mice were generated to disrupt Pkd2 in embryonic AP. Aqp(2ECE/+) Pkd(2f/f) (Pkd2ECE) mice were tamoxifen-inducted at P1 or P60 to inactivate Pkd2 in neonate or adult AP and their derivatives, respectively. All induced mice were sacrificed at P300. ...