Apyrase(三磷酸腺苷双磷酸酶)是一种能够催化ATP和ADP水解生成AMP及无机磷的酶,具有底物特异性、金属离子依赖性等特点,广泛应用于生物学研究、农业抗虫机制及医学领域。其功能包括调节胞外ATP浓度、参与细胞信号传递,并在植物防御反应中发挥重要作用。以下从多个维度展开说明。 催化机制与底物特异性 Ap...
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1. 1. Apyrase (ATP: diphosphohydrolase) has been found in the microsomal fraction of rat salivary gland, mammary gland and uterus. 2. 2. This enzyme, alrea... MA Valenzuela,J López,M Depix,... - 《Comparative Biochemistry & Physiology Part B Comparative Biochemistry》 被引量: 107发表:...
Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1. An extracellular ATPase (E-type ATPase) clone was isolated from a human brain cDNA library and sequenced. The transcript shows similarity to the previously... TM Smith...
The overexpression of the YND1 gene in thegda1 null mutant caused a significant increase in microsomal membrane-bound nucleoside phosphatase activity with a luminal orientation. The activity was equally high toward ADP/ATP, GDP/GTP, and UDP/UTP and ∼50% less toward CDP/CTP and thiamine ...
P2Y12orP2Y1inhibitorsreduceplateletdepositioninamicrofluidic 系统标签: apyraseplateletmicrofluidicthrombosisflowinhibitors P2Y12orP2Y1inhibitorsreduceplateletdepositioninamicrofluidicmodelofthrombosiswhileapyraselacksefficacyunderflowconditions†S.F.Maloneya,LawrenceF.Brassb,andS.L.DiamondaS.L.Diamond:sld@seas.upenn....
The , , expresses a gene, (Apy), that encodes an . The product of this gene is a secreted enzyme that facilitates hematophagy by preventing platelet aggregation in the . Apy gene expression is limited to the cells of the distal-lateral and medial lobes of the adult female salivary glands...
Since this N-glycosylation site is invariant in cell membrane eNTPDases, it is postulated that glycosylation of this residue near ACR1 is crucial for full enzymatic activity of the cell membrane NTPDases. 展开 关键词: NTPDase Apyrase Glycosylation Site-directed mutagenesis Lectin modulation ...