The combination of LDCs with other drug delivery systems, such as liposomes, nanoemulsions, micelles, solid lipid nanoparticles, and polymeric nanoparticles, could lead to synergistic effects and improved thera
cell membrane vesicles, bacterial outer membrane vesicles (OMVs) and extracellular vesicles (EVs) also have phospholipid membranes, which possess good biocompatibility and efficient drug loading capacity and exhibit potential for clinical translation. Here, we classified liposomes, cell membrane ...
Research design and methods: Here we explored the mechanism of ATB0,+-mediated entry of such liposomes. As ATB0,+ is highly-expressed in pancreatic cancer, we also examined the therapeutic utility of ATB0,+-targeted liposomal drug delivery to treat this cancer. Results: The uptake of lysine...
Types of nanoparticle core The nanoparticle core occupies a central position and key role in the drug delivery system. Some materials are used to make nanoparticles, which include metals (gold, Fe3O4, metal–organic frameworks, and hollow copper sulfide), polymers (PLGA, liposomes, and albumin)...
such as liposomes, polymeric nanoparticles, inorganic nanoparticles and organic/inorganic nanohybrids based on active constituents from TCMs have been extensively studied as a promising strategy to improve the delivery of active constituents from TCMs to achieve a higher therapeutic effect with fewer side ...
of the pH-responsive fusion ability and the intracellular distribution of antigens, the induction of humoral or cellular immunityin vivo, the induction of protective immunity against pathogens, and the treatment of tumor-bearing mice have been achieved using these liposomes. The design and function ...
1. Introduction The ultimate goal of targeted nanotechnology-based drug delivery systems (nanoDDSs) in cancer therapy is to improve the therapeutic index of cytotoxic agents by selectively increasing their concentration at the tumor site. Liposomes in particular have attracted much attention as site-...
liposomes, micelles, nanoemulsions, nanoparticulates and nanocrystals, dendrimers and nanogels. There are also sub-classifications of these systems depending on the materials that are used to form these systems. For example, nanoparticulates can be further divid...
To enhance cytosolic drug delivery from immunoliposomes present inside endosomes, a pH-dependent fusogenic peptide (diINF-7) resembling the NH2-terminal domain of influenza virus hemagglutinin HA-2 subunit was used. Functional characterization of this dimeric peptide showed its ability to induce fusion...
Liposomes, due to their structural similarity to cell membranes, play a significant role in drug delivery for bone regeneration. They have the following advantages: (1) physical encapsulation enhances drug stability and increases dosage; (2) the amphiphilic molecular layer of liposomes can be modified...