Focusing on aspects of the development of evidence-based approaches in bioinformatics and computational medicine, including data integration, methodologies, tools and models for clinical and translational medicine, it offers an essential introduction to clinical bioinformatics for clinical researchers and ...
The term "clinical proteomics" refers to the application of available proteomics technologies to current areas of clinical investigation. The ability to simultaneously and comprehensively examine changes in large numbers of proteins in the context of disease or other changes in physiological conditions hold...
Bioinformatic Challenges in Clinical Diagnostic Application of Targeted Next Generation Sequencing: Experience from Pheochromocytoma.Bioinformatic Challenges in Clinical Diagnostic Application of Targeted Next Generation Sequencing: Experience from Pheochromocytoma.doi:10.1371/journal.pone.0133210Recent...
have been demonstrated to affect the clinical efficacy of adoptive t cell therapy, such as tumor heterogeneity and antigen loss, hard trafficking and infiltration, immunosuppressive tumor microenvironment and t cell exhaustion. several strategies to improve the efficacy of adoptive t cell therapy have be...
To this end, we developed a bioinformatics protocol for personalized precision medicine by integrating the concepts of drug repurposing and drug combination. The protocol elucidates one or more drug combinations that are precisely adapted to individual gene expression profiles. This bioinformatics protocol ...
Patient-derived RPE cells and ROs for modeling RP could recapitulate the genotype–phenotype features of the disease. Due to clinical and genetic heterogeneity, different retinal degeneration phenotypes caused by intra-gene variations and the same phenotype caused by mutations in multiple genes could be...
reliable clinical biomarkers are still limited, restricted by the suboptimal methods in biomarker discovery. Nucleic acid aptamers nowadays could be used as a powerful tool in the discovery of protein biomarkers. Nucleic acid aptamers are single-strand oligonucleotides that can specifically bind to variou...
Application of Clinical Bioinformatics This bookelucidates how genetic, biological and medical information can be applied tothe development of personalized healthcare, medication and therapies. Focusingon aspects of the development of evidence-based approaches in bioinformati... X Wang,C Baumgartner,DC Sh...
Director of Chemistry, Center for Systems Biology, Massachusetts General Hospital; Assistant Professor of Medicine, Harvard Medical School Gad Getz, PhD Director of Bioinformatics, Krantz Center for Cancer Research and Department of Pathology; Paul C. Zamecnik Chair in Cancer Re...
Applications of consensus embedding are shown in the context of classification and clustering as applied to: (1) image partitioning of white matter and gray matter on 10 different synthetic brain MRI images corrupted with 18 different combinations of noise and bias field inhomogeneity, (2) classifica...