Methods We investigated APP processing in the absence of BACE1 activity upon pharmacological inhibition and siRNA knock down in CHO cells and primary neurons. For in vivo analysis, we used brain lysates of BACE1 KO mice and inhibitor treated animals. Epitope specific monoclonal antibodies were ...
The multiple cleavages of APP that occur in infected cells are produced in part by known components of the amyloidogenic APP processing pathway, i.e., host-cell β-secretase, γ-secretase, and caspase-3-like enzymes. These findings demonstrate that HSV-1 infection of neuronal cells can ...
Cognitively normal control subjects (n=170) and AD patients (n=92) were genotyped for 19 putative regulatory tagging SNPs within nine genes (APP, ADAM10, BACE1, BACE2, PSEN1, PSEN2, PEN2, NCSTN and APH1B) involved in the APP processing pathway. SNP genotypes were tested for their ...
We have previously shown that interrupting the CD40/CD40L interaction either pharmacologically or genetically resulted in the mitigation of amyloid precursor protein (APP) processing in animal and cellular models of AD. To date, the mechanism of action by which CD40/CD40L affects Abeta production and...
Transporting APP and secretases into the same subcellular organelles facilitates their interaction and favors APP processing. The role of APP and BACE1 trafficking in the amyloidgenic pathway and the underlying mechanisms for Aβ production are discussed in this review. In addition, the distinct ...
The secreted isoforms of the amyloid precursor protein (APP) that contain the Kunitz domain are also known as protease nexin 2 (PN2). Normal proteolytic processing of transmembrane APP, which results in the majority of soluble PN2, cleaves within the Alzheimer's A beta peptide, precluding A ...
Studies the role of beta-amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD). Processing pathways undergone by the APP; Role of... Zheng,Hui,Jiang,... - 《Cell》 被引量: 636发表: 1995年 Reduced Caudate and Nucleus Accumbens Response to Rewards in Unmedicated ...
Aim To investigate the effects of Curcumin on the APP processing in the amyloidogenic pathway in vitro and explore its mechanisms on Aβ generation inhibition.Methods Plasmids APPswe and BACE1-mychis were transiently co-transfected in SH-SY5Y cell by LipofectaminTM2000.The cell line then treated ...
APP processing APP processing （Hynes, T.R.1991）—— Hongxue Luo
感觉的处理通路为Sensory processing pathway is ( )。A.感觉—知觉—认识—记忆feeling perception cognition memoryB.感觉—知觉—认识—情感Feeling perception cognition emotionC.感觉—知觉—记忆—认识Feeling perception memory cognitionD.感觉—知觉—情感—认识F