In addition, various protein fragments derived from APP regulate synaptic plasticity and neural networks42,43,44,45,46. Thus, we cannot exclude that cell-nonautonomous effects of the loss of APP family function in excitatory neurons on other types of cells have been observed. For example, the ...
Schematic diagram of APP processing (not drawn in proportion). It is not clear whether caspases cleave membrane-associated APP forms or released AICD. Full size image The similarity in topology and proteolytic processing between APP and Notch suggest that APP may function as a membrane receptor lik...
Methods: To address this question, we studied synaptic transmission in cultured neurons from newborn APP deficient mice in vitro as well as dendritic spine density in the cerebral cortex from adult APP deficient mice in vivo applying long-term two-photon imaging. Results: We could demonstrate ...
Control of amyloid-beta-peptide generation by subcellular trafficking of the beta-amyloid precursor protein and beta-secretase. the context of other studies focused on the function of BACE1 and BACE2 and the role of subcellular trafficking in the proteolytic processing of βAPP.doi... J Walter -...
However, only a few studies have shown that CTF accumulation in APP processing is neurotoxic and causes synaptic loss, leading to long-term memory impairment in several AD models [4,5,6]. Transgenic mice expressing C99 fragments or injected with CTFβ showed impaired synaptic plasticity, long-...
Description: The monoclonal antibody 22C11 recognizes human, mouse, and rat APP (Amyloid Precursor Protein). APP is expressed in high abundance in the central nervous system and has three major isoforms resulting from alternative splicing. APP plays a role in synaptic formation and repair...
APP processing and synaptic function. Neuron. 2003;37(6):925–37. Article CAS PubMed Google Scholar Sheng JG, Price DL, Koliatsos VE. Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis. J Neurosci. 2002;22(22):...
Amyloidogenic processing of amyloid precursor protein (APP) produces Aβ peptides, the major component of hallmark AD senile plaques. Synaptic activity stimulates Aβ production, and Aβ promotes synaptic depression, suggesting Aβ mediates homeostatic plasticity of excitatory synapses. However, ...
APP processing APP processing （Hynes, T.R.1991）—— Hongxue Luo
While APLP2 and APP are functionally redundant, the exclusively CNS expressed APLP1, might have individual roles within the synaptic network. The proteolytic product of non-amyloidogenic APP processing, APPsα, emerged as a neurotrophic peptide that facilitates long-term potentiation (LTP) and ...