Furthermore, repeated administration of both memantine and propolis significantly restored the decreased ATP contents in the CA1 region of APP-KI mice. Finally, we confirmed that repeated administration of memantine at 1mg/kg p.o. and propolis at 100mg/kg p.o. for 8weeks failed to restore ...
detectable in APP/APLP2-DKO mice. Mechanistically, using APPsα-KI mice lacking transmembrane APP and expressing solely the secreted APPsα fragment we demonstrate that APPsα expression alone is sufficient to prevent the defects in spine density observed in APP-KO mice. Collectively, these studies ...
As a proof of concept, we delivered rAAV-mAICD in neonatal brain of 5XFAD mice to investigate if APP C-tail interaction with GαS could alleviate memory deficits in a model of amyloidosis. We employed the novel object recognition, the Y-maze, and the fear conditioning tasks to evaluate ...
Là một người yêu thích sự xê dịch, tôi luôn không ngừng tìm kiếm những cuộc hành trình mới. Trái tim tôi luôn thôi thúcChi tiết TẬP SAN “NGƯỜI PPJ” SỐ 19: VIẾNG MỘ ĐẠI TƯỚNG Chút nhân...
In mice treated with a potent BACE1 inhibitor, hippocampal long-term potentiation was reduced. Notably, when recombinant or synthetic Aη-α was applied on hippocampal slices ex vivo, long-term potentiation was lowered. Furthermore, in vivo single-cell two-photon calcium imaging showed that ...
(LP) improves cognitive impairment in 5XFAD and aged mice by regulating NF-κB-mediated BDNF expression. It was also found that treatment with LP can alleviate intestinal barrier damage and inhibit microglial activation. Therefore, increasing the abundance of LP in the intestine is of great ...
(coordinates: 0.6 mm posterior to bregma; lateral: −1.5 mm; dorsoventral: 1.7 mm) [25]. The mice were maintained for 12 weeks after the injection of the lentivirus. After the behavior test, the mice were killed by cervical dislocation and the brains were quickly removed for other ...
While many different IRAs are effective in treating T2D, their ability to treat AD depends on their ability to access the brain. Using125I labelled IRAs, we tested the ability of intravenously administered IRAs to cross the blood-brain barrier (BBB) in mice [65,66]. The results showed that...
Treatment of symptomatic APP/PS1 mice with complex I inhibitor improved energy homeostasis, synaptic activity, long-term potentiation, dendritic spine maturation, cognitive function and proteostasis, and reduced oxidative stress and inflammation in brain and periphery, ultimately blocking the ongoing ...
However, at 48 h after systemic injection of the non-fused VHH-DTPA-111In and the VHH-Fc-DTPA-111In fusion protein in transgenic mice, the specific brain uptake of VHH-Fc-DTPA-111In was not improved compared to non-fused VHH-DTPA-111In. Conclusion Using VHH-Fc conjugates increases the ...