Apolipoprotein E: structure, func- tion, and possible roles in Alzheimer's disease. Ann N Y Acad Sci 1996;777:139-45.R. Mahley, B. Nathan, and R. Pitas, Apolipoprotein E: Structure, function, and possible roles in Alzheimer’s disease, Ann NY Acad Sci 777 :139–145 (1996)....
Heterogeneity of apolipoprotein E epitope expression on human lipoproteins: importance for apolipoprotein E function. J. Lipid Res. 29, 1309 - 1325.Krul ES, Tlkkanen MJ, Schonfeld G. Heterogeneity of apolipoprotein E epitope expression on human lipoproteins: importance of apolipoprotein E function. J...
Apolipoprotein E (APOE) is a multifunctional protein with three isoforms (e2, e3, and e4) that correspond with diverse functional and pathological manifestations. Most notably, the e4 allele has been associated with an increased risk of cardiovascular disease, and is considered a prominent risk ...
OBJECTIVES The ε4 allele of apolipoprotein E (APOE) represents a major biological risk factor for late onset Alzheimer's disease. However, it is still not known whether the APOE genotype affects the progression of the disease, assessed by different functional methods. METHODS The study sample inc...
Which isoforms of apolipoprotein E (apoE) we inherit determine our risk of developing late-onset Alzheimer’s Disease (AD), but the mechanism underlying this link is poorly understood. In particular, the relevance of direct interactions between apoE and amyloid-β (Aβ) remains controversial. Here...
Apolipoprotein E (apoE) ε4 and hyperhomocysteinemia are risk factors for Alzheimer disease (AD). The dimerization of apoE3 by disulfide bonds between cysteine residues enhances apoE3 function to generate HDL. Because homocysteine (Hcy) harbors a thiol group, we examined whether Hcy interferes with...
Therapeutic approaches targeting apolipoprotein E function in Alzheimer's disease Mol Neurodegener, 15 (2020), p. 8 CrossrefView in ScopusGoogle Scholar 203 M. Safieh, A.D. Korczyn, D.M. Michaelson ApoE4: an emerging therapeutic target for Alzheimer's disease BMC Med, 17 (2019), p. 64...
Functional characterization of apolipoprotein E isoforms overexpressed in Escherichia coli. Apolipoprotein (apo) E plays an important role in lipid metabolism, and the major isoforms of apoE (apoE2, apoE3, and apoE4) have significantly different m... JA Morrow,KS Arnold,KH Weisgraber - 《Protein...
Apolipoprotein E is enriched in M2 macrophages-derived exosomes and highly expressed in M2-polarized macrophage To unravel the molecular mechanism responsible for the pro-migratory effect of M2-Exos, we analyzed their protein content by mass spectrometry. Among the proteins identified, 72 overlapping pr...
conclusions The apo E phenotype affects the serum MDA‐LDL concentration and forearm endothelial function in postmenopausal women.\ndoi:10.1111/j.1365-2265.2004.02145.xMikio TsudaDepartment of Obstetrics and Gynaecology,Mitsuhiro SanadaDepartment of Obstetrics and Gynaecology,Yukihito Higashi...