3. C类载脂蛋白 ApoC-I、ApoC-II、ApoC-III:存在于VLDL和HDL中,调节脂蛋白代谢酶的活性,如脂蛋白脂酶(LPL)。其中,ApoC-III的高水平与甘油三酯升高和心血管疾病风险增加相关。 4. D类载脂蛋白 主要存在于人类和其他生物血浆中,并与高密度脂蛋白(highdensity lipoprotein, HDL)结合。由于 ApoD 的结构及合成部...
Relationship between apolipoprotein C-Ⅲ concentrations and high-density lipoprotein subclass distribution. Metabolism, 2009, 58(5): 668-674L. Tian,J. Wu,M. Fu,Y. Xu,L. Jia.Relationship between apolipoprotein CIII concentrations and high-density lipoprotein subclass distribution. Metabolism . 2009...
Apolipoprotein CIII (ApoCIII) not only serves as an inhibitor of triglyceride hydrolysis but also participates in diabetes-related pathological events such as hyperactivation of voltage-gated Ca2+ (CaV) channels in the pancreatic β cell. However, nothing is known about the molecular mechanisms...
There is growing evidence that apolipoprotein C-III (apoC-III), a small exchangeable apolipoprotein carried in the circulation by VLDL and HDL1, is a master regulator of plasma TG homeostasis and downregulation of its expression has a cardiovasculo-protective effect2. ApoC-III inhibits the activity...
Apolipoprotein CIII (apoCIII) is associated with triglyceride-rich lipoprotein metabolism and has emerged as independent marker for risk of cardiovascular disease. The objective was to test whether apoCIII is regulated postprandially and whether apoCIII concentrations in native and chylomicron-free seru...
Zheng, C. et al. Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion. Eur. Heart J. 34, 615–624 (2013). Article CAS PubMed Google Scholar Gaidt, M. M. et al. Human monocytes engage an alternative inflammasome pathway. Immunity 44, 833–...
Evidences have suggested that proteins primarily related to plasma lipoprotein transport, such as apolipoprotein (apo) CIII and E, may significantly affect the process of body fat accumulation. We have previously observed an increased adiposity in response to a high fat diet (HFD) in mice ...
Apolipoprotein C-III (APO C-III) is a structural component of very-low-density and high-density lipoprotein particles and is an inhibitor of lipoprotein lipase. In a study of genetic variation of apolipoproteins in the Mayan population of the Yucatán peninsula, we observed a quantitative polymorp...
Among biomarkers shown to be most predictive of CVD in T2D are N-Terminal Prohormone B-type Natriuretic Peptide (NT-proBNP) and high-sensitivity Troponin T (hsTnT) [3]. Recent data also support the potential of Apolipoprotein CIII (apoCIII) as a predictive biomarker in the context of ...
Methods: We used isoforms of apolipoprotein C-III (apoC-III) as a marker for the biosynthesis of core 1 mucin type O-glycans. Plasma samples from patients with primary defects and secondary alterations in N-glycan biosynthesis were studied by apoC-III isofocusing. Results: Age-related reference...