A particularly interesting result of the AIM-HIGH trial is that baseline and on-study Lp(a) predicted CV events in both the control LDL-lowering therapy plus placebo and LDL-lowering therapy plus ERN arms, suggesting that Lp(a) still contributes to residual CV risk in patients achieving target...
the intensity of the emitted light is proportional to the Apolipoprotein B100 (APOB100) level in the sample or standard.Detection Range:62.5-4000pg/mlSensitivity:The minimum detectable dose of this kit is typically less than 22.3pg/ml.Specificity:This sandwich assay has high sensitivity and excell...
To produce clinically valid results, a test must accurately, precisely, and selectively measure the marker of interest. That is, it must be standardized. Accuracy refers to how closely the result obtained with 1 method corresponds to the result obtained with the standard method, precision to how...
The apolipoproteinB (ApoB) is the main component of very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), low-density lipoproteins (LDL) and lipoprotein (a); while ApoA1 represents the major high-density lipoproteins (HDL) Apo and is the main acceptor of cholesterol ...
A stable isotope kinetic study performed in obese patients has revealed that the VLDL and HDL apoE concentrations are increased in those with T2D as a result of increased production rates. In addition, HOMA-IR and HbA1c were positively correlated with the VLDL apoE production rate in those ...
Hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 studied with a stable isotope technique in men with visceral obesity. To test the hypothesis that the hepatic secretion of very-low-density lipoprotein (VLDL) apolipoprotein B-100 (apoB) is increased in men with visceral obes....
Three allelic variants of the APOE gene, e2, e3, and e4, deriving from two single-nucleotide polymorphisms—rs429358 (thymine, T; or cytosine, C), and rs7412(C or T)—result in single amino acid changes in the APOE protein (7–9). Presence of the APOE e4 allele has been strongly...
High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fatal myocardial infarction (AMORIS study): a prospective study. Lancet. 2001;358(9298):2026-203311755609PubMedGoogle ScholarCrossref 15. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of...
Therapeutic interventions that increase plasma high density lipoprotein (HDL) and apolipoprotein (apo) A-I levels have been reported to reduce plasma glucose levels and attenuate insulin resistance. The present study asks if this is a direct effect of increased glucose uptake by skeletal muscle. Incu...
B. et al. The amino acid sequence of human APOA-I, an apolipoprotein isolated from high density lipoproteins. Biochem. Biophys. Res. Commun. 80, 623–630 (1978). CAS PubMed Google Scholar Bojanovski, D. et al. Human apolipoprotein A-I isoprotein metabolism: proapoA-I conversion to ...