The suppressive effect of anandamide on apo A-I promoter activity in Hep G2 cells could be inhibited by CBR1 antagonist AM251 but not by AM630, a selective and potent CBR2 inhibitor. These results indicate that ECs directly suppress apo A-I gene expression in both hepatocytes and intestinal...
(A) Expression of miR-155 in ILC2s regulated by Apo-AI. (B-E) Correlation between miR-155 expression and GATA3, RORα, IL-5, and IL-13, respectively. (F and G) Effect of miR-155 inhibitor or mimics in regulation of GATA3 and RORα expression. (H and I) Effect of miR-155 ...
Results are expressed as percentage, 100% being the production of IL-1β or TNF-α measured in the absence of inhibitor (mean ± SD, n = 3). Apo A-I is the HS inhibitor of T-cell signaling of monocytes To determine whether apo A-I would display the inhibitory activity, various ...
the apolipoprotein b3304-3317 peptide as an inhibitor of the lipoprotein (a) :apolipoprotein b-containing lipoprotein interaction VN Trieu,U Olssont,WJ Mcconathy,... 被引量: 0发表: 2019年 Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine ...
using a series of in vitro and in vivo methods (including the single-molecule force spectroscopy technique BFP), as well as conducting human studies in healthy subjects, we identified that apoA-IV is a novel ligand of platelet αIIbβ3 integrin and an endogenous inhibitor of platelet aggregation...
SP-A (pulmonary surfactant-associated glycoprotein A) 肺表面活性蛋白A(抗原) SYVN1(synovial apoptosis inhibitor 1) 滑膜细胞凋亡抑制物1(抗体) SYK (Spleen tyrosine kinase) 非受体型酪氨酸激酶(抗原) Tau protein 微管相关蛋白(抗原) TGF-βR 1/ALK-5(TGF-beta receptor type I) 转移生长因子–β受体 ...
B. Lipoprotein (a) inhibits the generation of transforming growth factor beta: an endogenous inhibitor of smooth muscle cell migration. J. Cell Biol. 113, 1439–1445 (1991). 27. Grainger, D. J. et al. Proliferation of human smooth muscle cells promoted by lipoprotein (a). Science 260, ...
Identification of apolipoprotein D as a novel inhibitor of osteopontin-induced neoplastic transformation. Int J Oncol 29:... Osteopontin that associates with metabolism of calcium is one of the important factors in the development and prognosis of human breast cancer. The aim of ... D Jin,M El...
Conversely, the IF1 protein, a natural inhibitor of F1-ATPase activity, reverses the protective effects of apoA-I on endothelial cells (Radojkovic et al., 2009). The aim of this study was to determine the expression of SATP on early hEPC and its involvement in the effects of apoA-I ...
For example, in one non-limiting embodiment, the methods comprise the step of administering to the animal in need of treatment, a therapeutically effective amount of a apolipoprotein(a) inhibitor. The apolipoprotein(a) inhibitors of the present invention effectively inhibit the activity of the ...