APOEepsilon4 impacts up-regulation of brain-derived neurotrophic factor after a six-month stretch and aerobic exercise intervention in mild cognitively impaired elderly African Americans: A pilot study. Exp Gerontol. 2017;87(Pt A):129-36.
apolipoprotein e epsilon 4 (apoe‐ε4) genotype is associated with decreased 6‐month verbal memory performance after mild traumatic brain injury(载脂蛋白eε4(apoeε4)基因型与轻度脑外伤后6个月记忆功能下降相关) 文档格式: .pdf 文档大小:
Among APOE-epsilon4 carriers, depressed participants showed more cognitive decline (40.0%) than their nondepressed counterparts (28.6%), odds ratio = 2.89, 95% confidence interval: 1.03-8.12; p = .04, after controlling for age, gender, education, vascular risk factors/events, smoking, alcohol ...
Association of the APOE epsilon4 allele with disease activity in multiple sclerosis. OBJECTIVES: Allelic variants of the APOE gene are known to influence the course of many neurological diseases and there is increasing evidence that apolipo... N Evangelou,M Jackson,D Beeson,... - 《Journal of...
Objective: To test for an association between the apolipoprotein E (APOE) epsilon 4 allele and dementias with synucleinopathy.Design: Genetic case-control association study.Setting: Academic research.Patients: Autopsied subjects were classified into 5 categories: dementia with high-level Alzheimer disease...
We reported that the frequency of the epsilon2/epsilon4 genotype of the apolipoprotein E (APOE; GenBank AF286472) gene is significantly increased in primary progressive aphasia (PPA), one of the syndromes associated with FTD. Primary progressive aphasia is characterized by progressive language ...
OBJECTIVE: To determine whether APOE epsilon 4 predicts rate of cognitive change in incident and prevalent Alzheimer disease (AD). METHODS: Individuals were recruited from two longitudinal cohort studies-the Washington Heights and Inwood Columbia Aging Project (WHICAP; population-based) and the Predicto...
The presence of the epsilon4 genotype was associated with neither CI (p = 0.28) nor impairment on each neuropsychological test (p > 0.32; corrected for age, gender, disease duration, EDSS, depression and fatigue). The APOE genotype and CI were also not related in the subgroup of younger ...
APOE ε4: The most prevalent yet understudied risk factor for Alzheimer'sdisease APOE epsilon4: the most prevalent yet understudied risk factor for Alzheimer's disease. Alzheimers Dement. 2014; 10 (6):861–8. doi: 10.1016/j.jalz... DM Michaelson - 《Alzheimers & Dementia》 被引量: 152发...
Age and APOE-epsilon4 genotype influence the effect of physostigmine infusion on the in-vivo distribution volume of the muscarinic-2-receptor dependent tra... The -epsilon4 allele (-epsilon4) confers greater susceptibility to age-related disorders. Abnormalities in the cholinergic system are likely...