[0035] 根据本发明的一些方面,提供提高细胞内APOA1或ABCA1的表达的方法。在一些 实施例中,该些方法包括将在此披露的单链寡核巧酸中的任一种或多种递送至细胞。在一 些实施例中,将该单链寡核巧酸递送至细胞导致APOA1或ABCA1的表达水平大于(例如,至少50%大于)不包括该单链寡核巧酸的对照细胞中的APOA1或...
THP-1gene expression regulationapoA-1ABCA1C3Hypoxia plays a critical role in progression of atherosclerosis. Local oxygen deficiency in a plaque creates a specific microenvironment that alters the transcriptome of resident cells, particularly of macrophages. Reverse cholesterol t...
·麦克斯维根;珍妮·T·李 (74)专利代理机构 北京集佳知识产权代理有限公司 代理人 郑斌 (51)Int.CI A61K48/00; A61P9/10; A61P9/00; 权利要求说明书 说明书 幅图 (54)发明名称 用于调节 APOA1 和 ABCA1 表达的组合物和方法 (57)摘要 本发明的方面提供用于激活或增强 APOA1 或 ABCA1 的表达的单...
摘要: 目的:探讨姜黄素对APP/PS1双转基因鼠海马组织中三磷酸腺苷结合盒转运子A1 (ATP binding cassette transport proteinA1,ABCA1)和载脂蛋白A1(apolipoprotein A1,apoA1)的表达及血清中总胆固醇(total cholesterol,TC)和高密度脂蛋白... 查看全部>>
Indeed, a unique function of HDL is its ability to interact with ABCA1 via ApoA1. This process may be involved in the intestinal uptake of dietary sterol and antioxidants as well as reverse cholesterol transport from peripheral tissues to the liver. This article reviews some of the reasons ...
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英文名称 Apo A1 ELISA Kit 规格 48T/96T 服务 免费代测 货期 现货 保质期 6个月 保存 2-8℃ 检测方法 酶联免疫 试剂盒优势 灵敏性高、特异性强 样本 血清、血浆、尿液、组织匀浆 产品性状 液态 售卖地 全国 是否危险化学 否 可售卖地 北京;天津;河北;山西;内蒙古;辽宁;吉林;黑龙江;上海;江苏;浙江;安徽...
THP-1gene expression regulationapoA-1ABCA1C3Hypoxia plays a critical role in progression of atherosclerosis. Local oxygen deficiency in a plaque creates a specific microenvironment that alters the transcriptome of resident cells, particularly of macrophages. Reverse cholesterol transport from plaque to ...
THP-1gene expression regulationapoA-1ABCA1C3Hypoxia plays a critical role in progression of atherosclerosis. Local oxygen deficiency in a plaque creates a specific microenvironment that alters the transcriptome of resident cells, particularly of macrophages. Reverse cholesterol transport from plaque to ...
In addition, by using the single-stranded oligonucleotide, it is also provides a method for regulating the expression of APOA1 or ABCA1. Yet another aspect of the invention provides a method for selecting a candidate oligonucleotides to activate or increase expression of APOA1 or ABCA1.クリー...