We used a mammalian cell culture approach and followed heme insertion into both transiently- and endogenously-expressed apo- sGC beta. Although sGC is often associated with heat shock protein 90 (hsp90) in cells, the implications are unclear. Experiments that used pharmacological hsp90 inhibitors, ...
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Influence of cinaciguat on gastrointestinal motil- ity in apo-sGC mice. Neurogastroenterol Motil 2014;26:1573- 85.Cosyns SM, Huyghe L, Thoonen R, Stasch JP, Brouckaert P, Lefebvre RA. Influence of cinaciguat on gastrointestinal motility in apo-sGC mice. Neurogastroenterol Motil. 2014; 8(...
Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGCMosliciguatNitric oxide-insensitive soluble guanylate cyclasePulmonary diseasesSoluble guanylate cyclase activatorVentilation/perfusion mismatchBackground:Oxidative stress associated with severe cardiopulmonary diseases leads to ...
{gastrointestinal,apo-sGC,BAY 25-2667,cinaciguat}, language = {eng}, location = {London, UK}, number = {3}, publisher = {British Pharmacological Society}, title = {Cinaciguat in th...
Influence of cinaciguat on gastrointestinal motil- ity in apo-sGC mice. Neurogastroenterol Motil 2014;26:1573- 85. [Crossref]Cosyns SM, Huyghe L, Thoonen R, Stasch JP, Brouckaert P, Lefebvre RA. Influence of cinaciguat on gastrointestinal motil- ity in apo-sGC mice. Neurogastroenterol ...
Targeting native and apo-sGCdoi:10.1186/2050-6511-14-S1-O17Nitric OxideSmooth MusclePulmonary HypertensionPulmonary Arterial HypertensionArterial HypertensionMary StruthersSubharekha RaghavanRonald KimMichael MendelsohnBioMed CentralBMC Clinical Pharmacology
Mechanisms driving heme insertion into apo-sGC during its maturation in cellsdoi:10.1186/2050-6511-14-S1-O18Nitric OxideHeat ShockHeat Shock ProteinATPase ActivityMaturation ProcessDennis StuehrArnab GhoshAnindya SarkarYue DaiBioMed CentralBMC Clinical Pharmacology...
移植瘤免疫功能目的 探讨新型棉酚衍生物apogossypol对胃癌SGC7901移植瘤抑制及免疫功能之间的关系.方法 体外培养扩增SGC7901胃癌细胞,接种裸鼠,建立小鼠移植瘤模型.计算肿瘤的抑瘤率,测定自然杀伤(NK)细胞活性,腹腔巨噬细胞一氧化氮(NO)的 产生量,NK细胞活性,T淋巴细胞增殖能力及白细胞介素-2(IL-2)的活性.结果 ...
Relaxant effect of BAY 41-2272 and BAY 58-2667 in the gastrointestinal tract of apo-sGC micedoi:10.1186/1471-2210-11-S1-P19SarahCosynsJohannes-PeterStaschPeterBrouckaertRomainALefebvreSpringerBmc Pharmacology