Data on outcome in older (≥70 years) patients with acute promyelocytic leukemia after treatment with arsenic trioxide (ATO) compared with standard chemotherapy (CTX) is scarce. We evaluated 433 patients (median age, 73.4 years) treated either with ATO+
Acute Promyelocytic Leukemia (APL) in Very Elderly Patients: Real-Life behind ProtocolsIntroduction APL in the elderly is rare and about 5% of patients with APL are older than 70 years at diagnosis; compared to young adults, prognosis of older patients with APL remains poorer, due to the ...
Between April 2004 and December 2010, we conducted a prospective randomized controlled study comparing tamibarotene with all-trans retinoic acid (ATRA) in the maintenance therapy of newly diagnosed acute promyelocytic leukemia (APL), and here report the final results of this study with a median fol...
Keywords: acute myeloid leukemia; PTPN11 mutations; prevalence; clinical characteristics; prognosis 1 Introduction Acute myeloid leukemia (AML) is a clonal malignant proliferative disease of primitive cells in the hematopoietic system, and whole-genome sequencing has revealed the complexity and high heteroge...
1,123 Consecutive Adults with Non-APL Acute Myeloid Leukemia: The Mayo Clinic Experience Standard statistical methods were used for analysis of overall survival, calculated from the initial diagnosis of AML to date of death or last follow-up; analyses were performed both in the absence and in th...
Arsenic trioxide maintenance takes a bite of the APLThe article offers information on a study regarding the role of maintenance treatment with arsenic trioxide in the survival of adults with acute promyelocytic leukemia. Several drugs included in the standard chemotherapy that was used to treat ...
Acute lymphoblastic leukemia a comprehensive review with emphasis on biology and therapy Also, intensive consolidation-intensification may improve survival rates. Most patients benefit from maintenance therapy, but the dose schedule must be optimized... JE Cortes,HM Kantarjian - 《Cancer》 被引量: 335...
Background: Acute promyelocytic leukemia (APL) is a highly curable cancer, but it is not clear whether it is also necessary to monitor long-term toxicity in “cured” patients who survive for more than five years, which is critical to ensuring maximum survival in APL patients. Methods: A to...
Prognosis of medullary thyroid carcinoma: demographic, clinical, and pathologic predictors of survival in 1252 cases. Cancer. 2006;107(9):2134-42. 126. Koehler JA, Kain T, Drucker DJ. Gluca- gon-like peptide-1 receptor activation inhibits growth and augments apoptosis in murine CT26 colon ...
Powell BL, Moser B, Stock W, Gallagher RE, Willman CL, Stone RM, et al. Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710. Blood. 2010;116(19):3751–7. ...