What happens if I miss a dose? Take the missed dose on the same day you remember it. Take your next dose at the regular time and stay on your twice-daily schedule.Do nottake two doses at one time. Get your prescription refilled before you run out of medicine completely. ...
[4] Wong PC, et al. Dose-Dependent Antithrombotic Effects of Apixaban, an Oral Direct Factor Xa Inhibitor, in Prevention and Treatment of Thrombosis in Rabbit Models of Arteriovenous-Shunt and Venous Thrombosis at Doses That Preserve Hemostasis. Blood 110: 933 (2007). ...
Apixaban has multiple routes of elimination. Of the administered apixaban dose in humans, approximately 25% was recovered as metabolites, with the majority recovered in faeces. Renal excretion of apixaban accounts for approximately 27% of total clearance. There are also additional contributions from bil...
Therefore, it is recommended to adjust the dose of apixaban in patients with NVAF according to the following factors: age ≥ 80 years, weight ≥ 60 kg, and SCr ≥ 1.5 mg/dL. Patients who meet the above two criteria can reduce the dose of apixaban (2.5 mg twice daily). Approximately ...
All apixaban metabolites account for approximately 32% of the excreted dose though the structure of all metabolites are not well defined. Apixaban is mainly metabolized by cytochrome p450(CYP)3A4 and to a lesser extent by CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2J2. 排泄 56% of an ...
Apixaban exposure increases dose proportionally for oral doses up to 10mg. Apixaban is rapidly absorbed, with maximum concentration occurring 3鈥 4h after oral administration, and has a half-life of approximately 12h. Elimination occurs via multiple pathways including metabolism, biliary excretion, and...
[4] Wong PC, et al. Dose-Dependent Antithrombotic Effects of Apixaban, an Oral Direct Factor Xa Inhibitor, in Prevention and Treatment of Thrombosis in Rabbit Models of Arteriovenous-Shunt and Venous Thrombosis at Doses That Preserve Hemostasis. Blood 110: 933 (2007). ...
Systemic exposures of unbound apixaban; in male and female rats at the highest dose tested (600 mg/kg/day) were 2 and 4 times, respectively, the human exposure. Apixaban; had no effect on fertility in male or female rats when given at doses up to 600 mg/kg/day, a dose resulting in...
[4] Wong PC, et al. Dose-Dependent Antithrombotic Effects of Apixaban, an Oral Direct Factor Xa Inhibitor, in Prevention and Treatment of Thrombosis in Rabbit Models of Arteriovenous-Shunt and Venous Thrombosis at Doses That Preserve Hemostasis. Blood 110: 933 (2007). ...
Define apixaban. apixaban synonyms, apixaban pronunciation, apixaban translation, English dictionary definition of apixaban. apixaban. Translations. English: apixaban n apixabán m. Spanish / Español: n apixabán m.