The 9.1 Mbp Cryptosporidium parvum genome (3,807 genes) has been sequenced. This intestinal parasite has no apicoplast and its degenerate mitochondria has lost its genome (Abrahamsen MS et al 2004 Science 304:441). signal peptide, transit peptide, toxoplasmosis, microneme, rhoptry; Wilson RJM ...
32,33, as determined by loss of signal for the Trx-like protein 1 (ATrx1, apicoplast membrane marker) (Supplementary Fig.2f)52. Partial apicoplast-loss was further validated by employing Cpn60 and DAPI staining (apicoplast genome) (Supplementary ...
Publication of the draft complete genome of P. falciparum. Article CAS PubMed Google Scholar Daubenberger C. A. et al. The N-terminal domain of glyceraldehyde-3-phosphate dehydrogenase of the apicomplexan Plasmodium falciparum mediates GTPase Rab2-dependent recruitment to membranes. Biol. Chem. ...
摘要: This chapter describes the basic structure of apicoplast genome and apicoplast division, and discusses the function of apicoplast (fatty acid synthesis, isopentyl diphosphate synthesis, haem biosynthesis and iron-sulfur cluster assembly).关键词:...
Like plant chloroplasts, apicoplasts are semi-autonomous with their own genome and expression machinery. In addition, apicoplasts import numerous proteins encoded by nuclear genes. These nuclear genes largely derive from the endosymbiont through a process of intracellular gene relocation. The exact role...
genome, whose organization resembles that of chloroplasts, albeit highly reduced (∼35kb). It mainly encodes housekeeping genes such as rRNAs and tRNAs and thus most proteins required for the organelle’s function are encoded in the nucleus. Those destined for 0166-6851/$ – see front matter ...
Apicoplast translation, transcription and genome replica- tion: targets for antimalarial antibiotics. Trends Parasitol. 24, 279-284.Dahl, E. L., and Rosenthal, P. J. (2008) Apicoplast translation, transcrip- tion and genome replication: targets for antimalarial antibiotics. Trends Parasitol. 24, ...
microti. Specifically, this genome encodes genes involved in maintenance of the apicoplast DNA, transcription, translation and maturation of organellar proteins, which contains 2 subunits of ribosomal RNAs, 17 ribosomal proteins, 1 EF-Tu elongation factor (tufA), 5 DNA-dependent RNA polymerase beta ...
The DNA polymerase module of the Pfprex enzyme (PfpPol) is responsible for duplication of the genome of the apicoplast organelle in the malaria parasite. We show that PfpPol can misincorporate oxidized nucleotides such as 8oxodGTP opposite dA. This event
GENOMEPOLYMERASEEVOLUTIONGYRASEThe human malaria parasite Plasmodium falciparum genome is among the most A + T rich, with low complexity regions (LCRs) inserted in coding sequences including those for proteins targeted to its essential relict plastid (apicoplast). Replication of the apicoplast...