The activity of this enhancer is initially broad but eventually becomes restricted to the mesenchyme surrounding the liver. We demonstrate that the function of this enhancer in transgenic embryos is dependent upon highly conserved Forkhead and GATA transcription factor binding sites, which are bound by...
EMP4 contains nine 35-amino acid PPR motifs and an N-terminal mitochondrion-targeted sequence peptide, which was confirmed by a translational EMP4-green fluorescent protein fusion that localized to mitochondria. Molecular analyses further suggest that EMP4 is necessary to regulate the correct ...
Strikingly, the induction of myocardial infarction (MI) leads to significantly increased mortality in Timp4-/- mice primarily due to left ventricular rupture. The post-MI mortality of Timp4-/- mice is reduced by administration of a synthetic MMP inhibitor. Furthermore, combining the genetic ...
In the present study, we sought to determine the signaling pathway through which BMP4 up-regulates TRPC expression. Methods: We employed recombinant human BMP4 (rhBMP4) to determine the effects of BMP4 on NADPH oxidase 4 (NOX4) and reactive oxygen species (ROS) production in rat distal ...
To address regulatory factors of Smad1, we determined that BMP4 and its receptor are increased in diabetic glomeruli and that diabetic Smad1-Tg and wild-type mice treated with a BMP4-neutralizing antibody exhibit decreased Smad1 phosphorylation and ∼40% less mesangial expansion than those ...
Runx1 contributes to the functional switching of bone morphogenetic protein 4 (BMP4) from neurite outgrowth promoting to suppressing in dorsal root ganglion[J] . Masaaki Yoshikawa,Tomoyuki Masuda,Azusa Kobayashi,Kouji Senzaki,Shigeru Ozaki,Shin Aizawa,Takashi Shiga.Molecular and Cellular Neuroscience . ...
In addition, vestibular structures, pathologic changes, and the vestibular function of chondrocyte-specific Smad4 knockout mice were compared to those of the control group. We found that the expression of Smad4 in the inner ear was delayed compared with that of BMP4. Moreover, chondrocyte-...
PurposeAn altered expression of bone morphogenetic protein 4 (BMP4) has been found in malignant melanoma cells. We performed an associationstudy to investigate the effect of putative functional single nucleotide polymorphisms (SNPs) of BMP4 on development of cutaneousmelanoma (CM).Mario...
Real-time quantitative PCR and Western blotting revealed that treatment with BMP4 (50 ng/ml, 60 h) increased TRPCI, TRPC4, and TRPC6 mRNA and protein expression in growth-arrested rat distal PASMCs. Moreover, in comparison to vehicle control, cells treated with BMP4 also exhibited enhanced ...
A computational study of a series of N[sub 1]- and/or C[sub 6]-alkyl-5,6-dihydrothymine diastereomers at theory levels up to MP4(SDTQ)/6-31G[sup *]//HF/6-31G[sup *] and MP2/6-311G[sup **]//HF/6-31G[sup *] has demonstrated the respective importance of the substituents...