The conformation of lividomycin A (1) bound to an aminoglycoside antibiotic 3'-phosphotransferase (APH (3')-IIIa), an enzyme that confers bacterial aminoglycoside resistance, was recently characterized via NMR spectroscopy. In contrast to the previously studied 4,5-disubstituted aminoglycosides, the ...
Here we have simulated conditions todetermine whether the aminoglycoside phosphotransferaseAPH(3')-IIIa is capable of evolving increased enzymatic activitycatalyzing the aminnoglycoside amikacin as a substrate.APH(3')-IIIa was subjected to four rounds of mutation, tworounds of error-prone PCR and two...
Crystal Structure Of 3',5"-Aminoglycoside Phosphotransferase Type IIIa ADP Kanamycin A Complex The spectra of the pyridinols, quinolinols, isoquinolinols, quinolones, and isoquinolones have been calculated by a variable-尾 procedure within the Parise... DH Fong,AM Berghuis 被引量: 0发表: 2002...
Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues. Authors: Janek Szychowski, Jiro Kondo, Omar Zahr … APh A Women's Auxiliary annual meeting preview Authors:
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gariepinus PA IIIa (juvenile–adult isotype) cross-reacted to a rather similar extent despite a weaker cross-reaction of anti-PA IIIa with larval–juvenile isotypes. On the other hand, antibodies raised against H. longifilis PA IV (an exclusively adult isotype) recognized markedly only H. ...
Methods and materials Treatment-naive patients with histologically confirmed NSCLC, stage IIIA/IIIB, received either 39 Gy in 13 fractions as RT alone (arm A, n = 31) or 2鈥 3 platinum-based CHT cycles followed by 10 Gy in a single fraction or 16 Gy in 2 fractions separated by one ...
Analysis of the pi-pi stacking interactions between the aminoglycoside antibiotic kinase APH(3')-IIIa and its nucleotide ligands - Boehr, Farley, et al. - 2002Boehr DD, Farley AR, Wright GD, Cox JR. Analysis of the pi-pi stacking interactions between the aminoglycoside antibiotic kinase APH(...
(2005) Establishing the principles of recognition in the adenine-binding region of an aminoglycoside antibiotic kinase [APH(3')-IIIa], Biochemistry 44, 12445-12453.Boehr DD,Farley AR,LaRonde FJ,Murdock TR,Wright GD,Cox JR.Establishing the principles of recognition in the adenine-binding region ...