接下来，我们将简要概述APD334（Etrasimod，艾曲莫德）的研发背景。这款药物是由Arena公司精心研发的选择性鞘氨醇1-磷酸（S1P）受体调节剂，它在治疗免疫和炎症介导的疾病方面，如溃疡性结肠炎、克罗恩病和特应性皮炎，展现出显著的治疗潜力。在推进APD334的临床开发过程中，大规模合成成为了关键环节，其中关键苄氯...
APD334 CAS号: 1206123-37-6 英文名: Etrasimod 英文别名: Neflamapimod;APD334;CS-2445;Etrasimod;APD-334;APD 334;Etrasimod(APD334);Etrasimod, 10 mM in DMSO;APD334; APD-334; APD 334; ETRASIMOD;Etrasimod,APD-334,LPL Receptor,Inhibitor,inhibit,APD 334,Lysophospholipid Receptor;(R)-2-...
中文名称:APD334英文名称:Etrasimod CAS:1206123-37-6品牌:普善 产地:陕西保存条件:2-8°C 纯度规格:99%产品类别:医药中间体 级别:医药级别名:化合物ETRASIMOD;(R)-2-(7-((4-环戊基-3-(三氟甲基)苄基)氧基)-1,2,3,4-四氢环戊二烯并[B]吲哚-3-基)乙酸;(ChemicalbookR)-2-(7-((4-环戊基...
Etrasimod (APD334) 是高效的有选择性和口服活性的S1P1受体拮抗剂,在CHO细胞中的IC50值为1.88 nM。 ields of Application : Etrasimod (APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1(S1P1) receptor with an IC50 value of 1.88 nM in CHO cells. ...
Etrasimod (formerly known as APD334) is Arena Pharmaceuticals’ therapeutic candidate to treat autoimmune diseases like multiple sclerosis (MS) and ulcerative colitis. The drug is an oral formulation agonist (a substance which exerts its effect after binding to a particular receptor) that targets ...
Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEEtrasimodarginineCat.No.:HY-135432CASNo.:1206123-97-8Synonyms:APD334arginine分子式:C₃₂H₄₀F₃N₅O₅分子量:631.69作用靶点:LPLReceptor作用通路:GPCR/GProtein储存方式:Pleasestoretheproductundertherecommendedcondi...
DatasheetofEtrasimod(APD334) Description: Etrasimod(APD334)isapotent,selectiveandorallyavailableantagonistofthesphingosine-1-phosphate-1(S1P1)receptorwith anIC50valueof1.88nMinCHOcells. ChemicalInformation CatalogDC10040 Purityofcurrentbatch:>98% MolecularWeight(MW)457.48 MolecularFormulaC26H26F3NO3 CASNo...
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