研究人员开发了多种参数性统计模型,其中性能突出的是我们今天的主角:APC模型(全称为Age-period-cohort model),该模型可以同时解释影响疾病时间变化趋势的三大效应——年龄效应、时期效应、队列效应(一般认为,疾病的时间变化趋势通常用年龄效应、时期效应、队列效应、随机变异来解释)。
定义:age-period-cohort model. 年龄效应(age effects):结局变量随着个体年龄的变化,其可以由生理上的变化/社会经验的积累/社会角色或地位的变化或者这些综合因素而引起。年龄效应反应个体生命历程的生物和社会过程。我们在一般模型中会加入年龄变量作为控制项,将因变量在年龄上的变化做出散点图,这条线就是因变量的年...
新兴先进控制技术：如非线性控制、鲁棒控制等。目前应用广泛且效果良好的先进过程控制方法是模型预测控制，所以在很多讨论APC的情况都是指MPC。02 模型预测控制MPC MPC（Model Predictive Control），又称RHC, Receding Horizon Control，是一种进阶过程控制方法。它以多变量预估为核心，采用过程模型预测未来时刻的输出。用...
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The mouse provides an excellent in vivo system with which to model human diseases and to test therapies. Mutations in the Adenomatous polyposis coli (APC) gene are required to initiate familial adenomatous polyposis (FAP) and are also important in sporadic colorectal cancer tumorigenesis. The (multi...
MPC(Model Predictive Control),又称RHC, Receding Horizon Control,是一种进阶过程控制方法。 它以多变量预估为核心,采用过程模型预测未来时刻的输出。 用对象的实际输出与模型预测输出的差值修正过程模型,从而把若干个要控制的变量控制在一个希望的工控点上,把装置整体推向最佳状态。 模型预测的形式有动态矩阵控制(DMC...
·GE (Continental Controls process-model based control, and MVC) ·Gensym (G2 products) ·Honeywell (Profit MAX, Profit Suite) ·Hyperion (DMCplusTM) ·Ipcos (INCA) ·Knowledgescape ·Knowledge Process Solutions (IPC) ·LineStream (ADRC) ...
Preliminary modeling suggested that indirect exposures from PCDDs/PCDFs at the 95th percentile level for the site where APC deposition rates were highest could potentially exceed the tolerable daily soil intake (TDSI) but this warrants further study given the model limitations. These results offer an...
型号/modelsurt5000xlich 额定容量/in5000va/3500w 输入电压/input voltage range(160vac～280vac) 输出电压/output voltage range220vac±2%(电池模式)可设置为220、230或240 输出电压 输出频率/output frequency50/60 hz +/- 3 hz 用户可调 +/- 0.1 ...
mouse model (APC cKO) that recapitulates features of human IS.•APC deletion increases β-catenin levels and frequency of EPSCs.•Neonatal spasms and aberrant cortical activity progress to spontaneous seizures.•We identify novel molecular pathways (APC/β-catenin/Wnt signaling) in a model of...