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Ethics declarations Competing interests There is a patent on this work, filed by Harvard University on behalf of K.L.S. and R.W.K. Additional information Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Supplement...
Ethics declarations Competing interests L.V. received consultancy fees from Bayer, MSD, Genentech, Servier and Pierre Fabre, but these had no relation to the content of this publication.Additional information Peer review information Nature thanks Hans Clevers, James DeGregori and Toshiro Sato for the...
All mice were used in accordance with the Australian Code of Practice for the Care and Use of Animals for Scientific Purposes, and were approved by the University of Newcastle Animal Care and Ethics Committee. Oocytes were collected from mice injected with 10 IU equine serum gonadotropin (...
The interplay between E2 and E3 enzymes regulates the polyubiquitination of substrates in eukaryotes. Among the several RING-domain E3 ligases in humans, many utilize two distinct E2s for polyubiquitination. For example, the cell cycle regulatory E3, human anaphase-promoting complex/cyclosome (APC/C)...