Taken together, it is clear from neuroimaging studies across several different disorders that apathy is most commonly associated with changes in the metabolic, gross and functional anatomy of fronto-striatal circuits. Moreover, the most common deficit appears to be to VS, and to portions of interco...
Apathy and impulsivity are debilitating conditions associated with many neuropsychiatric conditions, and expressed to variable degrees in healthy people. While some theories suggest that they lie at different ends of a continuum, others suggest their possible co-existence. Surprisingly little is known, ho...
of all the different classes of pharmacological agents, D2/D3 receptor agonists such as pramipexole appear to be the most efficient treatment for the wide range of behavioral deficits induced by dopaminergic lesions. Lesion-based rodent models, therefore, appear to be relevant tools for studying th...