Gene Set Enrichment analysis for AP-1 complex family members. a) Summary of the over-represented co-localised TFs with TRE motifs after integration. b) Summary of over-represented co-occurring TFs with CRE motifs after integration. For complete list please refer to Additional file 3: Table S3...
However, a complex in vivo model to support this concept was still missing. 2. Experimental systems to study the role of AP-1 in skin A very attractive in vivo system to study the function of Jun proteins in proliferation and differentiation is the skin. The formation and maintenance of ...
Clearly, the cellular processes control- ling taste cell function are complex and further studies will be needed to connect the signaling pathways that control taste cell maintenance with the expression of taste-specific genes. Discussion Although it is clear that taste cell renewal has significant ...
This SRGAP family includes four members in mammals: SRGAP1, SRGAP2, SRGAP3 and ARHGAP4 [6], and these proteins have GAP activity for Rac [7,8,9], which indicates that SRGAPs regulate Rac activity. SRGAP consists of three functional domains, F-BAR, RhoGAP, SH3, and a functionally ...
anomalous endothelial cell functionality, disordered vascular structure, elevated microvascular density, and augmented permeability, which aim to supply more oxygen, nutrients, and metabolic waste to the abnormal growth of solid tissues [3]. The tumor microenvironment (TME) is a complex and integrated ...
Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells J Virol, 74 (2000), pp. 9637-9645 View in ScopusGoogle Scholar 20 J Friborg, W Kong, MO Hottiger, GJ Nabel p53 inhibition...
The supershift assays using antibodies against specific proteins of the AP1 family identified Jun-D and c-Fos as two members in the hARE-protein complex observed in band shift assays.doi:10.1016/S0021-9258(19)36948-0Y LiAK JaiswalJournal of Biological Chemistry...
gaps in developing an opioid response plan. Using participatory approaches, particularly in the 'From Design to Action' co-design workshop, health design methods allow teams to gain an in-depth grasp of capacity building requirements for complex public health challenges, such as the overdose crisis...
Binding of a substrate produces an enzyme–substrate complex. It is likely that enzymes speed up chemical reactions in part because the enzyme–substrate complex undergoes a set of temporary and reversible changes that cause the substrates to be oriented toward each other in an optimal position to...
, death, survival and differentiation and is induced by a plethora of physiological stimuli and environmental insults. AP-1, as the downstream of MAPK cascade, can be activated by any or all three main of the MAPK pathways through phosphorylation of distinct substrates14. The AP-1 complex is ...