Maintenance of the oncogenic phenotype depends on the accumulation of genetic changes, as well as epigenetic events such as the induction of specific promotion-relevant effector genes. Certain target genes of the AP-1 transcription factor complex are thought to mediate in neoplastic transformation, alt...
The AP1 complex typically comprises two proteins, a Jun (c-Jun, JunB, and JunD) and a Fos (c-Fos, FosB, Fra1, and Fra2). These proteins can form both homodimers and heterodimers among-themselves and can interact with additional proteins; thus, dissecting their individual roles has been ...
AP-1 transcription factors and the BAF complex mediate signal-dependent enhancer selection. Mol Cell. 2017;68:1067–82.e12. Article PubMed CAS PubMed Central Google Scholar Deng T, Karin M. c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK....
Here, we show that the RanBP2/RanGAP1*SUMO1/Ubc9 complex functions as an autonomous disassembly machine with a preference for the export receptor Crm1. We describe three in vitro reconstituted disassembly intermediates, which show binding of a Crm1 export complex via two FG-repeat patches, ...
Two tandem AP1 binding sites with dyad symmetry are required for enhancer activity and for DNA-protein complex formation with members of the c-fos/c-jun family. The requirement for AP1 activation suggested a role for the mitogen-activated protein kinase (MAPK) signaling pathway in regulating ...
complex. Alpha-2-macroglobulin receptor-associated protein, also known as low-density lipoprotein receptor-related protein-associated protein 1, RAP, and LRPAP1, is a 39 kDa protein and a member of the alpha-2-MRAP family. It is a receptor antagonist that interacts with several members of the...
The supershift assays using antibodies against specific proteins of the AP1 family identified Jun-D and c-Fos as two members in the hARE-protein complex observed in band shift assays.Previous article in issue Next article in issue View PDFCited by (0)...
▸ Endogenous RanBP2 is quantitatively associated with sumoylated RanGAP1 and Ubc9 ▸ RanBP2/RanGAP1∗SUMO1/Ubc9 is a multisubunit SUMO E3 ligase, not an E2/E3 complex ▸ Two nonequivalent Ubc9 molecules are required for sumoylation by the RanBP2 complex ▸ Complex formation activates...
ATP6V0A2 encodes the a2 subunit, which localizes the V-ATPase complex to the Golgi apparatus8. In addition to the core V-ATPase subunits, two accessory proteins are known in vertebrates, that is, ATP6AP1 (also known as Ac45) and ATP6AP2 (also known as (Pro-) renin receptor)9. ...
Gene Set Enrichment analysis for AP-1 complex family members. a) Summary of the over-represented co-localised TFs with TRE motifs after integration. b) Summary of over-represented co-occurring TFs with CRE motifs after integration. For complete list please refer to Additional file 3: Table S3...