During the past year, we have accomplished this goal by deriving a panel of 5 genes, including AP-2alpha, any two of which when hypermethylated in DCIS, preliminarily tracks with patients who develop recurrent disease. Each marker, in the main, has a much higher incidence of hypermethylation ...
#自然简报 【数学“天才”们也输给AI了】国际数学奥林匹克竞赛(IMO)专门面向极具数学天赋的高中生,其试题以超高难度著称。近日,由谷歌DeepMind开发的人工智能(AI)解题系统AlphaGeometry2的表现超过了IMO金牌获得者的平均水平。该系统解答出了IMO过去25年全部几何真题中的84%——而初代AlphaGeometry的解题成功率只有54...
2.4. Lp-PLA2 Distribution Determination To determine the Lp-PLA2 distribution across HDL and apoB-containing lipoproteins, after precipitating the apoB lipoproteins from serum, HDL-Lp-PLA2 mass was measured using a Lp-PLA2 enzyme-linked immunosorbent assay (ELISA) kit (Changhai, Cristal Day Biot...
Transcription factor AP-2alpha has been implicated as a cell-type-specific regulator of gene expression during vertebrate embryogenesis based on its expression pattern in neural crest cells, ectoderm, and the nervous system in mouse, chick, and frog embryos. AP-2alpha is prominently expressed in ...
本发明公开了一种抑制人AP-2alpha基因表达的siRNA及其在治疗宫颈癌中的用途.本发明利用生物数据库获得人AP-2alpha基因序列,设计一组能诱发人AP-2alpha的RNA干扰的siRNA,通过化学法合成一定量的siRNA,从而特异性降低人AP-2alpha基因的mRNA水平和蛋白表达水平,同时该siRNA极大地降低了转录因子AP-2alpha在宫颈癌细胞...
Transcriptional repression of the alpha 7 nicotinic acetylcholine receptor subunit gene (CHRNA7) by Activating Protein-2 alpha (AP-2 alpha). J. Biol. Chem. 286, 42123e42132.Finlay-Schultz J, Canastar A, Short M, El Gazzar M, Coughlan C, Leonard S (2011) Transcriptio...
Repression of transcription factor AP-2 alpha by PPARγ reveals a novel transcriptional circuit in basal-squamous bladder cancerBladder cancerNuclear receptorsThe discovery of bladder cancer transcriptional subtypes provides an opportunity to identify high risk patients, and tailor disease management. Recent...
Pituitary tumor AP-2alpha recognizes a cryptic promoter in intron 4 of fibroblast growth factor receptor 4. J Biol Chem 2003; 278(22):19597-19602.Yu S, Asa SL, Weigel RJ, Ezzat S 2003 Pituitary tumor AP-2alpha recognizes a cryptic promoter in intron 4 of fibroblast growth factor ...
AP2 alphaAdipogenesis3T3-L1 cellsPreadipocytesAdipogenesis has an important role in regulating energy balance, tissue homeostasis and disease pathogenesis. 3T3-L1 preadipocytes have been widely used as an in vitro model for studying adipocyte differentiation. We here show that KCTD1, a member of the...
A peroxisome proliferator-actived receptor (PPAR) response element (RE) in the promoter region of the adaptor-related protein complex 2, alpha 2 subunit (AP2α2) of mouse heart has been identified. The steroid hormone nuclear PPARs and the retinoid X receptors (RXRs) are important ...