During the past year, we have accomplished this goal by deriving a panel of 5 genes, including AP-2alpha, any two of which when hypermethylated in DCIS, preliminarily tracks with patients who develop recurrent disease. Each marker, in the main, has a much higher incidence of hypermethylation ...
A Necessary Requirement for AP–2 in Normal Lens and Retinal Development as Indicated by a Lens–Specific Knockout of AP–2. PURPOSE. To determine the metabolic conditions that provide maintenance of viability for cultured rat RPE cells and to determine whether monocarboxylates s... GF Pontorier...
Collectively, these studies support a tumor suppressor role for AP-2alpha in the gastrointesti Co免疫沉淀反应实验提供的证据为AP2alpha, betacatenin和腺瘤polyposis杆菌(APC)蛋白质之间的互作用在老鼠小肠黏膜,并且主要人的colorectal癌症。 共同,这些研究支持一个肿瘤遏抑器角色为AP2alpha在胃肠道,并且建议AP2...
Li M , Li X , Wang E & Luo E ( 2013 ). Upregulation of Toll-like receptor 2 gene expression by acetylation of AP-2 alpha in THP-1 cells, a human monocytic cell line. Int J Biochem Cell Biol 45 , 1594 – 1599 .Li M, Li X, Wang E and Luo E: Upregulation of Toll-like...
本发明公开了一种抑制人AP-2alpha基因表达的siRNA及其在治疗宫颈癌中的用途.本发明利用生物数据库获得人AP-2alpha基因序列,设计一组能诱发人AP-2alpha的RNA干扰的siRNA,通过化学法合成一定量的siRNA,从而特异性降低人AP-2alpha基因的mRNA水平和蛋白表达水平,同时该siRNA极大地降低了转录因子AP-2alpha在宫颈癌细胞...
Transcriptional repression of the alpha 7 nicotinic acetylcholine receptor subunit gene (CHRNA7) by Activating Protein-2 alpha (AP-2 alpha). J. Biol. Chem. 286, 42123e42132.Finlay-Schultz J, Canastar A, Short M, El Gazzar M, Coughlan C, Leonard S (2011) Transcriptio...
Transcription factor AP-2alpha has been implicated as a cell-type-specific regulator of gene expression during vertebrate embryogenesis based on its expression pattern in neural crest cells, ectoderm, and the nervous system in mouse, chick, and frog embryos. AP-2alpha is prominently expressed in ...
A peroxisome proliferator-actived receptor (PPAR) response element (RE) in the promoter region of the adaptor-related protein complex 2, alpha 2 subunit (AP2α2) of mouse heart has been identified. The steroid hormone nuclear PPARs and the retinoid X receptors (RXRs) are important ...
Presents information on a study which determined the crystal structure of the alpha-subunit appendage of alkaline phosphatase-2 (AP-2) adaptors by multiwavelength anomalous diffraction phasing. Materials and methods of the study; Results and discussion.Traub...
A urokinase receptor promoter element (-152/-135) bound with an AP-2-alpha-related protein and SP1 is required for the induction of gene expression by PMA and SRCThe urokinase-type plasminogen activator receptor (u-PAR) promotes extracellular matrix degradation, invasion and metastasis. A first ...