接下来,作者利用HOMER分析了潜在的TFs结合位点,他们系统阐述了22种细胞类型在年轻和衰老小鼠中特异性的TF结合基序特征以及TFs重分布。结合已公布的人类细胞成熟过程数据集,作者发现衰老和成熟过程中开放的染色质区域都具有高AP-1结合位点的富集以...
Recent studies involving induced pluripotent stem cell (iPSC) reprogramming in mice and monocyte-to-macrophage differentiation in humans have revealed a role for the transcription factor (TF) activator protein 1 (AP-1) in chromatin accessibility. Enhancer selection may be determined not only by cell...
AP-1成员之间存在着相互促进或拮抗作用。c-Jun是AP-1的主要成分,如前所述,它可通过亮氨酸拉链与其他蛋白形成复合物,如Jun-B、Jun-D、ATF家族成员,不同的组合其作用不尽相同。在某些情况下,Jun-B可与Jun、Fos或Fos-B形成非活化的异源二聚体,通过竞争与AP-1位点的结合来抑制AP-1的活化,Jun-B表现出抑制c...
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目的探讨c-Jun/激活蛋白1(AP-1)在活化的凝血因子Ⅶa促进SW620细胞增殖,迁移过程中的作用及其调控机制.方法 Western blot检测人结肠癌SW620细胞中Ⅶa,组织因子(TF),蛋白酶激活受体2(PAR2),细胞外调节蛋白激酶1/2(ERK1/2)抑制剂U0126,p38抑制剂SB203580处理后c-Jun,磷酸化c-Jun(p-c-Jun)的蛋白水平变化;...
作者的结论是,衰老反应是由一个通用的三层TF网络结构编码的,并且强烈依赖于AP-1先锋TFs实现的增强景观的开发,通过与定居者和移民TFs的局部、多样和动态交互来编排OIS转录程序。层次问题:AP-1先驱TF的功能紊乱,但没有其他TF,逆转衰老时钟。先锋TFs代表了操纵细胞命运的有吸引力的靶点,用于不同的研究和治疗目的。因此...
TF footprinting was performed on pooled ATAC-seq datasets from 3 biologically independent experiments. Plots show the average co-binding profiles across replicates. b, Heatmap showing the overlap between TF lexicons (rows) and chromatin states, ChIP-seq and ATAC-seq peaks (columns) collected from...
Here, we use single cell RNA-sequencing of patient tumors to identify three prognostic surface markers (LYPD3, TACSTD2, and LY6D) which correlate with nMRTF and resistance to SMO inhibitors. The nMRTF cell state resembles transit-amplifying cells of the hair follicle matrix, with AP-1 and...
J our nal of N ant ong U ni ver si t y (M edi cal Sci ences)2018∶38(1)1激活蛋白1(act i vat or pr ot ei n-1,A P-1)的简介1.1A P-1的结构和功能A P-1转录因子家族是由Jun(v-J un,c-J un,J unB 和J unD ),Fos(v-Fos,c-Fos,Fos B ,Fr al 和Fr a2),A TF(A TF2...
We found that the TF BACH2 restrains terminal differentiation to enable generation of long-lived memory cells and protective immunity after viral infection. BACH2 was recruited to enhancers, where it limited expression of TCR-driven genes by attenuating the availability of activator protein-1 (AP-...