Next, we examined the levels of R-loops after codepletion of either XPF or XPG with NKAP. More R-loops were accumulated when either XPF or XPG was knocked down with NKAP compared to knockdown of NKAP alone (Fig.9I and J, and Supplementary Fig.S15A and B). We noticed that R-loops...
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(p= 0.05). In combination with 2 Gy IR, 8.4 and 16.7 µM Xevinapant clearly reduced survival compared with the treatment with IR alone in most of the cells as well (p= 0.05). UD-SSC-2 cells were more resistant, and the survival fraction of the irradiated cells decreased only at ...