AP-1 includes members of the Jun adoi:10.1007/978-3-0348-8468-6_4Anthony M. ManningManning AM (2000) Small molecule regulators of AP-1 and NFκB. In: LG Letts, DW Morgan (eds): Inflammatory processes: Molecular mechanisms and therapeutic oppor- tunities. Birkhauser Verlag, Basel, 23-...
Discovery of Nonpeptidic Small-Molecule AP-1 Inhibitors: Lead Hopping Based on a Three-Dimensional Pharmacophore Model K,Chaki H,Takakura T, et al.Discovery of nonpeptidic small-molecule AP-1 inhibitors: lead hopping based on a three-dimensional pharmacophore model. Journ... Keiichi,Tsuchida...
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在这个指标中,可以看见有AP针对小面积的(APsmall) / 中等面积的(APmedium) / 大面积的(APlarge)三种指标。 其中小目标的定义为:area < 322 的目标 其中中目标的定义为: 322 < area < 962 的目标 其中大目标的定义为:area > 962 的目标 Average Recall (AR): ...
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Membrane binding of AP-1/γ1 is blocked by BFA treatment. BFA inhibits Sec7-domain containing GEF proteins, like BIG1/2, which generate Arf1GTP. Two proteins of this small GTPase have to bind γ1 and β1 to recruit the AP-1/γ1 complex onto membranes. Thus γ2 membrane binding is ...
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AP-1 自动过滤器说明书 Model “AP-1”FABRICATED Bulletin 513.1 automatic strainer
The small G protein Arf1 regulates the spatiotemporal recruitment of AP-1 and also drives a conformational change favoring an interaction with cargo proteins. A recent crystal structure andexperiments highlighted potential residues mediating the AP-1/Arf1 interaction and the unlocking of the complex....