Article Open access Published: 08 October 2020 AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma Catherine D. Yao, Daniel Haensel, Sadhana Gaddam, Tiffany Patel, Scott X. Atwood, Kavita Y. Sarin, Ramon J. Whitson, Siegen Mc...
A plethora of physiological and pathological stimuli induce and activate a group of DNA binding proteins that form AP-1 dimers. These proteins include the Jun, Fos and ATF subgroups of transcription factors. Recent studies using cells and mice deficient
Nature Cancer volume 4, pages 1508–1525 (2023)Cite this article 17k Accesses 18 Citations 114 Altmetric Metrics details Abstract The PDCD1-encoded immune checkpoint receptor PD-1 is a key tumor suppressor in T cells that is recurrently inactivated in T cell non-Hodgkin lymphomas (T-NHLs). ...
Two shRNA target sequences specific for EpCAM (sh1, sh2) and a scrambled control sequence were cloned into the pSicoR-puromycin vector as previously described [32]. shRNA constructs were transfected into HEK293T cells with VSVG and Δ8.9, and viral supernatants were collected at 48 and 72...
近年来,酒店多采用商用无线AP来搭建无线网络,下面介绍一种丰润达酒店无线覆盖解决方案,无线接入设备主要以吸顶式无线AP为主。 一.无线网络设备AP部署 1.本次AP设备全部采用内置高增益天线; 2.设备在无线覆盖区的任何一个位置接收到的无线信号在频道上没有重叠; ...
产品活性:TERT activator-1 是端粒酶逆转录酶 (TERT) 的小分子激活剂,可通过 MEK/ERK/AP-1 信号级联促进 TERT 的转录。TERT activator-1 能够促进成体神经发生和增强神经肌肉。TERT activator-1 可减轻高龄小鼠的细胞衰老和全身炎症,可用于衰老的研究。
关于个人所得税APP绑定社保卡的问题,以下是绑定步骤:1、下载并登录个人所得税APP;2、进入绑定社保卡界面,寻找与“社保卡绑定”或“实名认证”相关的选项;3、按照提示完成绑定,输入必要信息并进行安全认证。用户在操作过程中应确保信息准确,并妥善保管社保卡和密码。
磐正AP48+ GTR型主板说明书:[4]1 本篇为《磐正AP48+ GTR型主板说明书》，主要介绍该产品的使用方法以及常见故障解决方案。
经Aponvie获批,在美国,医生现在可以为患者提供更方便的静脉注射,以快速、一致和可靠的方式提供同样有效的治疗,持续48小时,患者术后可以有更好的体验。 Aponvie是首个也是唯一一种用于预防术后恶心和呕吐的P物质/神经激肽-1(NK1)受体拮抗剂IV制剂。Aponvie旨在通过30秒的静脉注射直接递送阿瑞匹坦,与FDA批准适用于...
[46,47,48], activating invasion and metastasis [22], tumour-promoting inflammation [49], and avoiding immune destruction [33]. AP-1 proteins are also implicated in the pathogenesis of leukemia and lymphoma where these transcription factors can act as oncogenes [50,51] or tumour suppressors [...