A majority of respondents (65.9%) reported that they would accept an increase in TE risk to reduce the risk of a major bleeding event; 86.4% are willing to randomize patients with a mechanical aortic valve to a target INR of 2.0 (range 1.5–2.5) if they had no risk factors for TE ...
The LOWERING-IT study was a prospective, open-label, single-center randomized controlled trial that compared the thromboembolic and bleeding events between 2 different anticoagulation intensity levels in low-risk patients undergoing a single aortic mechanical prosthetic valve replacement. The 2 anticoagulatio...
Heart valve prosthesisThrombosisAspirinBioprosthetic valveBackground: The optimal medical strategy for prevention of thromboembolic events after surgical bioprosthetic aortic valve replacement (BAVR) is still debated. The objective of this study was to compare warfarin therapy (target INR of 2.0 to 3.0) ...
BACKGROUND :Scarce data are available on the long-term outcomes of different regimens of oral anticoagulation in an all comer population of patients undergoing aortic valve replacement with a bileaflet mechanical heart valve. METHODS :Outcomes of 88 patients discharged with a target INR of 2.0 (LOW...
Heart Valve Prosthesis ImplantationIn spite of antithrombotic therapy, the thromboembolic risk after aortic valve replacement appears to be high for the first 3 months after surgical intervention (3.6%), especially during the first 10 postoperative days.We have previously shown that 100 mg of aspirin...
Background The optimal medical strategy for prevention of thromboembolic events after surgical bioprosthetic aortic valve replacement (BAVR) is still debated. The objective of this study was to compare warfarin therapy (target INR of 2.0 to 3.0) with aspirin 150 mg daily as antithrombotic therapy ...
We conducted a post-hoc sub-analysis of the LOWERING-IT database to test the safety and feasibility of a low-level oral anticoagulant regime in low-risk patients with aortic LivaNova prosthetic valve replacement. The study population included 148 patients randomized to a low INR target (1.5–...
The results of the SURE–AVr Registry demonstrated that the proposed Lower–INR Target is safe and feasible after Bicarbon aortic mechanical valve replacement. The low–intensity anticoagulation strategy is associated with a low risk of hemorrhagic events without any increase of thromboembolic ...
Aortic valve replacementMechanical prosthetic valveAnticoagulationLong-term resultsThe long-term safety, efficacy, and outcomes of low-intensity anticoagulation for mechanical heart valves remain unclear. This study aimed to evaluate the long-term outcomes of low-intensity anticoagulation therapy after aortic...
At the time of surgery, an 18-cm linear thrombus(Fig. 2) was removed, aortotomy was then performed,and aortic valve replacement was performed with ON-X21 mm (ON-X Life Technologies Inc., Austin, TX, USA)mechanical prosthesis. PostoperativeDoppler revealedbilateral deep vein thrombosis extending...