CLASSIFICATIONofvirusSTRAINS IsdoneonthebasisofantigenicityofNP(nucleoprotein)andMP(matrixprotein)intothreemaingroups:InfluenzaA-HAundergoesminorandoccasionalmajorchanges-veryimportant. -NAsomevariation. InfluenzaB)UndergoesrelativelyslowchangeinHAwithtime.Knownonlyinman. ...
The drugs identified to inhibit SARS-CoV-2 infection/replication in cell culture assays were summarized in Table 1. Table 1. A list of approved drugs that have anti-SARS-CoV-2 activities (<5 μM of IC50) in cell culture. drug nameclassificationanti-SARS-CoV-2 activity (cell type used)...
This makes it extremely urgent to develop drugs that directly affect enteroviruses and hinder their development and spread in infected organisms. In this review, we cover the classification of enteroviruses, mention the most common enterovirus infections and their clinical man- ifestations, and ...
Therefore, the interest in these secretions due their potential has been increased for the development of new drugs. Among these substances, are peptides known to act as a defense substance for animals with antifungal and antibacterial actions capable to permeable into mammalian cells (Conlon, 2011...
such as nanoparticles57,77, surfactants or drugs. As an example, monocarpin is a highly efficient antiviral monoglyceride, shown to be effective against enveloped viruses, including VSV, HSV, visna virus and HIV114. Thorgeirsdottir et al.115tested the antiviral activity on a range of monocarp...
The most targeted protein in these in silico approaches is the main protease (Mpro), for which 150 drugs have been suggested (50 of which approved by the FDA), followed by the spike protein (S), with 47 suggested drugs. The most suggested drug against Mpro is Lopinavir and ritonavir52,...
public health implications of HCV drugs. N Engl J Med. 2015;373(27):2678-2680. doi:10.1056/NEJMe1513245 PubMedGoogle ScholarCrossref 3. Strader DB, Seeff LB. A brief history of the treatment of viral hepatitis C. Clin Liver Dis (Hoboken). 2012;1(1):6-11. ...
[24,34]. In addition, several studies have reported the potential use of its essential oil and crude extracts as therapeutic substances, mainly in the treatment of burns, gastroenteritis, antinociceptive and antioxidant drugs [35–37]. However,H. triquetrifoliumis one of the least studied species...
Antiviral therapy is one of these fields wherein CPPs are harnessed to develop new therapeutics and improve the properties of current antiviral drugs (Delcroix and Riley, 2010). Since most of the therapeutic targets of antiviral agents (i.e., viruses) are located inside the cells, CPPs are ...
Natural marine products have been found to be an important source of drugs and drug leads. These natural products are secondary metabolites which enhance survival fitness and may serve as chemical weapons against bacteria, fungi, viruses and small or large animals [[6], [7], [8]]. Most of...