This happens because while the antibiotic is killing most of the bacteria, a small group may survive. Over time, certain groups of bacteria may then adapt to the antibiotics. Of course, resistant bacteria can spread in the same manner as non-resistant bacteria. So, the best way to prevent ...
sufficient to create selection pressure but not high enough to prevent replication completely. The principles needed to minimize this problem are well understood from experience withantibiotic resistancein bacteria andcancer chemotherapy. Antiviral agents should be administered in sufficiently high dosage and...
Mm 46115, a new antiviral antibiotic from Actinomadura pelletieri. Characteristics of the producing cultures, fermentation, isolation, physico-chemical and biological properties J. Antibiot., 43 (11) (1990), pp. 1387-1393, 10.7164/antibiotics.43.1387 View in ScopusGoogle Scholar Astani et al., 201...
The HepG2.2.15 cell line (with the HBV ayw genome) was maintained as described above, but the medium was additionally supplemented with the antibiotic G418 (200 μg/ml). AAV vector production and purification AAV vectors carrying shRNAs targeting HBV and TGF-β were packaged with AAV2, ...
Bacteria and archaea have developed multiple antiviral mechanisms, and genomic evidence indicates that several of these antiviral systems co-occur in the same strain. Here, we introduce DefenseFinder, a tool that automatically detects known antiviral sys
1988). Similarly, aphidicolin, a diterpene-type antibiotic produced by Cephalosporium aphidicola Petch, inhibited the growth of either HSV-1 or HSV-2, in vitro and in vivo (Bucknall et al. 1973). In vitro results demonstrated that aphidicolin, administered on infected human embryonic lung cells,...
The ability to treat resistant pathogens is a significant advantage of nanoparticles over antiviral and antibiotic drugs which often target one component of a pathogen and thus are susceptible to resistance [139], [25]. In addition to antiviral activity, the antibacterial properties of metal ...
Drug dosing schedules are often based on a parameter called the area under the curve (AUC), where the curve represents a plot of drug concentration in human serum versus the time after delivery of the antibiotic or other drug into the human. One currently favored approach to dosing within the...
The novel antibiotic, Piptamine, has been isolated from this fungus (Schlegel et al. 2000). Pisha et al. (1995) found, in mice studies, that betulinic acid, a pentacyclic triterpene, was specifically toxic to melanoma without adverse effects to the host. Farnsworth et al. (1995) found ...
5804558 Protegrins 1998-09-08 Lehrer et al. 5464823 Mammalian antibiotic peptides 1995-11-07 Lehrer et al. 514/13 5459235 Antimicrobial peptides antibodies and nucleic acid molecules from bovine neutrophils 1995-10-17 Selsted et al.Other References: Tam et al., “Membranolytic selectivity of ...