Analysis of the molecules in the pipeline demonstrates that antituberculosis agents, either antimicrobial or adjuvant, are rarely compliant with the most common medicinal chemistry rules and largely evade the boundaries of drug-likeness, resulting in a "stand-alone" pharmaceutical class. In this ...
网络抗结核剂;抗结核菌类;抗结核病药 网络释义
Antituberculosis Agentsansamycin derivativesantituberculosis agentsD‐cycloserinein vitro testingisoniazidpyrazinamidestreptomycinthiacetazonedoi:10.1128/9781555815929.ch43André BryskierJacques GrossetJohn Wiley & Sons, Ltd
Lee, R., Hurdle, J., Liu, J.et al.Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.Nat Med20, 152–158 (2014). https://doi.org/10.1038/nm.3458 Download citation Received25 October 2013 ...
www.nature.com/scientificreports OPEN Discovery of novel antituberculosis agents among 3‑ phe nyl‑5‑ (1‑ph enyl‑1H‑[1,2,3]triazol‑4‑ yl)‑[1,2,4] oxadiazole derivatives targeting aminoacyl‑tRNA ...
Multicaulin, miltirone, synthesis, antituberculosisFour multicaulin and miltirone-like phenanthrene derivatives were synthesised and evaluated as antituberculosis agents. The crucial step of the synthesis was Pschorr coupling of 4-(3-isopropyl-4-methoxyphenyl)-2-(2-aminophenyl)ethane (13) to give 2...
In recent studies some urea derivatives have been identified as potent anti-tuberculosis agents by targeting mycobacterial membrane protein large 3(MmpL3). However, this compound series as exemplified by AU1235 exhibited poor in vitro pharmacokinetic profile. With AU1235 as the lead, we have identif...
Tuberculosis remains one of the world’s deadliest communicable diseases, novel anti-tuberculosis agents are urgently needed due to severe drug resistance and the co-epidemic of tuberculosis/human immunodeficiency virus. Here, we show the isolation of six anti-mycobacterial ilamycin congeners (1–6) ...
Criswell et al., “Mutations Conferring Aminoglycoside and Spectinomycin Resistance in Borrelia burgdorferi,” Antimicrobial Agents and Chemotherapy. vol. 50, No. 2 pp. 445-452 (2006). Davies, B., and Morris, T., “Physiological Parameters in Laboratory Animals and Humans,” Pharmaceutical Resea...
3D-QSAR study of ring-substituted quinoline class of anti-tuberculosis agents A 3D-QSAR analysis of a new class of ring-substituted quinolines with anti-tuberculosis activity has been carried out by three methods鈥擟omparative Molecu... A Nayyar,A Malde,R Jain,... - 《Bioorganic & ...