To lower lipoprotein(a), two antisense oligonucleotides have been developed, one targeting apolipoprotein B and one targeting apolipoprotein(a). Mipomersen is an antisense oligonucleotide targeting apolipoprotein B and thereby reducing levels of all apolipoprotein B containing lipoproteins in the circulation....
美['æntɪsens] 英['æntɪsens] 网络反义;反义基因;抗转录疗法 英英 网络释义 例句 释义: 全部,反义,反义基因,抗转录疗法 更多例句筛选
Among the various therapeutic platforms amenable to selective inhibition of Lp(a), antisense oligonucleotide (ASO) drugs have emerged as a promising approach in lowering Lp(a) levels in the clinical setting. ASOs represent the third major therapeutic discovery platform, distinct from small molecule ...
Under a Creative Commons license open accessHigh levels of plasma apolipoprotein B-100 (apoB-100), the principal apolipoprotein of LDL, are associated with cardiovascular disease. We hypothesized that suppression of apoB-100 mRNA by an antisense oligonucleotide (ASO) would reduce LDL cholesterol (LD...
There was no effect of the controlantisenseoligonucleotide on lipoprotein levels or oxidative parameters. 使用反义核苷酸链安慰剂不会引起脂蛋白水平和氧化参数的改变. 互联网 Result After A 549 was infected by recombinant retroviral vector expressingantisenseANG, ANG protein level decreased greatly. ...
Apolipoprotein B (APOB) is an integral part of the LDL, VLDL, IDL, Lp(a) and chylomicron lipoprotein particles. The APOB pre-mRNA consists of 29 constitutively-spliced exons. APOB exists as two natural isoforms: the full-length APOB100 isoform, assembled
Under a Creative Commons license open archiveAbstract Delivery of antisense oligodesoxynucleotides (ODN) into primary cells is a specific strategy for research with therapeutic perspectives but transfection-associated difficulties. We established the technique of magnetofection to enhance ODN delivery at low...
Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB. BMC Mol Biol. 2007; 8:3. [PubMed: 17233885]Khoo B, Roca X, Chew SL, Krainer AR: Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of ...
The gap-widened antisense oligonucleotide of the present invention have been shown to have an improved therapeutic index as compared to a corresponding antisense oligonucleotide having a 5-10-5 MOE gamer antisense oligonucletide with the same sequence. The gap-widened antisense oligonucleotides of the...
The invention also provides for an antisense oligonucleotide conjugate comprising the oligomer (A) according to the invention, and at least one non-nucleotide or non-polynucleotide moiety covalently attached to said oligomer (C), optionally via a linker region (B and/or Y) positioned between the ...