Antisense oligonucleotide technology can be used to investigate a circular but not linear RNA-mediated function for its encoded gene locusantisense oligonucleotidepremature transcription terminationcircular RNAlinear RNAAs a class of powerful molecular tool, antisense oligonucleotides (ASOs) are not only ...
Also found in:Thesaurus,Medical,Encyclopedia,Wikipedia. Related to antisense:Antisense strand,Antisense drugs an·ti·sense (ăn′tē-sĕns′, ăn′tī-) adj. Of or relating to a nucleotide sequence that is complementary to a sequence of messenger RNA. When antisense DNA or RNA is added ...
2024年3月13日,反义寡核苷酸(Antisense Oligonucleotide, ASO)领域的领军企业Ionis Pharmaceutics 公布了ION224在MASH治疗临床试验中的积极结果。根据披露信息,试验达到主要终点,所有试验组NAS评分至少降低2分的比例均有明显改善,且达到关键次要终点。 01 临床数据 此次公布的II期临床研究是一项多中心、随机、双盲、安慰剂...
Two decades after antisense oligonucleotides (ASOs) were initially identified as agents capable of modulating RNA processing and protein expression, the first antisense oligonucleotide (ASO) therapies have now been approved for the treatment of neurologi
Some of the efforts to advance this technology into useful therapies have focused on developing alternative chemistries to optimize the stability, specificity, affinity, and activity ofnucleic acidoligomers.1–6For the most part, improvements inoligonucleotidechemistry have not improved their in...
Figure 1.Antisense oligonucleotide (ASO) mechanisms of action.ASOs can modulate gene expression through RNase H1 – mediated recognition of an RNA:DNA hybrid followed by degradation of the target RNA. Alternatively, ASOs can bind to an RNA functional domain to sterically block proteins or other nuc...
coupling AS with NMD14. In fact, a striking number of splicing factors autoregulate their own expression through this coupling mechanism15,16. As the expression of a broad class of physiological transcripts can be downregulated by AS-NMD17, we reasoned that antisense-oligonucleotide (ASO)-mediated...
Antisense technology is now beginning to deliver on its promise to treat diseases by targeting RNA. Nine single-stranded antisense oligonucleotide (ASO) drugs representing four chemical classes, two mechanisms of action and four routes of administration have been approved for commercial use, including ...
In August 2021, a Phase 1clinical trialwas initiated withTAKC-02[267], an inhaled locked nucleic acid-modified GapmeR ASO (a short DNAantisense oligonucleotidestructures with RNA-like segments on both sides of the sequence) targeting theRNA binding proteinMex3B for the treatment of severe asthma...
The term “antisense oligonucleotide” (ASO) refers to an oligomer or polymer of nucleosides, such as naturally-occurring nucleosides or modified forms thereof, that are covalently linked to each other through internucleotide linkages. The ASO useful for the disclosure includes at least one non-natur...