Antiprotons have been proposed for cancer therapy due to enhanced dose deposition provided by antiproton-nucleon annihilation. We assessed cellular DNA damage and relative biological effectiveness (RBE) of a clinically relevant antiproton beam. Despite a modest LET (~19keV/μm), antiproton spread ...
functional groupradiation therapyradioimagingBackground The recent advances in the production and storing of antiprotons inspire further research regarding using an antiproton particle beam in cancer therapy. In this work, an overview study of the chemical properties that govern the reactions between ...
Biological validation of new radiotherapy modalities is essential to understand their therapeutic potential. Antiprotons have been proposed for cancer therapy due to enhanced dose deposition provided by antiproton-nucleon annihilation. We assessed cellul
It is a further object of the invention to provide prophylactic treatment to a human patient who is on a therapy known to have significant gastrointestinal side effects or is about to begin such a therapy, in order to avoid or e such side effects. It is a further object of the invention ...
radiation therapy/ antiproton beamradiotherapyionizing radiationlethal DNA lesionscancer cellsRadiotherapy employs ionizing radiation to induce lethal DNA lesions in cancer cells while minimizing damage to healthy tissues. Due to their pattern of energy deposition, better therapeutic outcomes can, in theory,...
Aim The motivation for the article is to grant an improved understanding of the processes involved in antiproton particle鈥恇eam cancer therapy as the antiproton comes to rest, in terms of the impact of molecular chemical properties on the antiproton annihilation site of the biomolecule. Methods ...
whole brain radiation therapyBackground To access the prognostic significance of HER-2 overexpression, the effect of trastuzumab and the cause of death in patients with brain metastases (BM) from bre...
Cancer therapyBeam profilometryReal-time imagingThe use of heavy charged particles for cancer therapy has the potential for a significant improvement of the therapeutic window compared to standard X-ray treatments. This is due to the improved energy deposition profile, exhibiting a well-defined peak ...
Conclusion: As awareness of second cancer risk grows, a standard scheme for estimating secondary dose from particle therapy will be all the more important. Our scheme allows for detailed characterization of the peripheral field and dose estimation can be made for non-target organs by weighting dose...
Practical, Experimental/ cancercellular biophysicsproton beamsradiation therapyradioisotopesthoriumtumoursuranium/ antiproton annihilationuranium nucleithorium nucleiIt is proposed to kill cancer cells by a combined treatment involving the bombardment of a tumor with antiprotons and the introduction of U 238 ...