Nature Structural & Molecular Biology volume 27, pages 119–126 (2020)Cite this article 4146 Accesses 6 Altmetric Metrics details Abstract A single enzyme active site that catalyzes multiple reactions is a well-established biochemical theme, but how one nuclease site cleaves both DNA strands of a ...
This study investigated the influence of the nature of oligonucleotides on the abilities to form antiparallel and parallel duplexes. Base pairing of homopurine DNA, 2'-O-MeRNA and RNA oligonucleotides with respective homopyrimidine DNA, 2'-O-MeRNA and RNA as well as chimeric oligonucleotides ...
M Teplova,DJ Patel - 《Nature Structural & Molecular Biology》 被引量: 196发表: 2008年 Structural basis for GC recognition in the DNA minor groove Antiparallel side-by-side pairings of two aromatic amino acids, imidazole (Im) and pyrrole (Py), distinguish G·C from C·G, and both from...
- 《Nature》 被引量: 2097发表: 2002年 Crystal structure of recombinant human interleukin-4. The crystal structure of recombinant human interleukin-4 (rhuIL-4) was initially determined at 3.5-A resolution by multiple isomorphous replacement techniq... M.R. Walter,W.J. Cook,B.G. Zhao,......
Figure 4.7.(a) Parallel and (b) anti-parallel β-sheets showing hydrogen bonds, but omitting side chains (c) parallel and (d) anti-parallel β-sheets illustrating the pleated nature of the sheet. (b)(fromVoet and Voet, 2004); (d)(FromBranden and Tooze, 1991. Reproduced by permission ...
Aβ42 oligomers play key roles in the pathogenesis of Alzheimer disease, but their structures remain elusive partly due to their transient nature. Here, we show that Aβ42 in a fusion construct can be trapped in a stable oligomer state, which recapitulates characteristics of prefibrillar Aβ42...
OPEN Heredity (2017) 119, 339–348 Official journal of the Genetics Society www.nature.com/hdy ORIGINAL ARTICLE Heritable gene expression differences between lake and stream stickleback include both parallel and antiparallel components D Hanson, J Hu, AP Hendry and RDH Barrett The repeated phenotypic...
The DNA tetramer d(CpGpCpG) or CGCG crystallizes from high-salt solution as a left-handed double helix, the Z' helix. Its structure differs from that of th... Drew,Takano,Tanaka,... - 《Nature》 被引量: 584发表: 1980年 Peptides and genes coding for scorpion toxins that affect ion-...
- 《Nature》 被引量: 434发表: 1993年 Solution Structure of the Link Module: A Hyaluronan-Binding Domain Involved in Extracellular Matrix Stability and Cell Migration Link modules are hyaluronan-binding domains found in proteins involved in the assembly of extracellular matrix, cell adhesion, and ...
Approximately 2.5 kb of DNA which encompasses the Eip40 gene has been sequenced. Analysis of this sequence shows that Eip40 encodes a Drosophila homologue of the enzyme cystathionase. The complementary DNA strand, which produces an 1800 N transcript, has a 645 N open reading frame (ORF). ...