The false-negative rate judged against IFA differed from assay to assay and disease to disease and was mostly <10%. Conclusions: In this study, the sensitivities of EIAs and IFA were largely comparable. However, EIAs without HEp-2 extracts included had a low sensitivity but a high specificity...
Twitter Google Share on Facebook antinuclear antibody Also found in:Thesaurus,Medical,Acronyms,Encyclopedia. n.Abbr.ANA Any of various antibodies that react with nuclear antigens such as nucleic acids and histones and are often present in the blood of people with systemic autoimmune rheumatic diseases...
Immunofluorescence assay (IFA) has been the standard method for antinuclear antibodies (ANA). To simplify and standardize the ANA test, generic ANA solid phase enzyme immunoassay has been promoted. The objective of the present work has been to study the relationship with IFA and the clinical usefu...
Anti DNA antibodies have the resistance to double stranded DNA (DS, DNA) and anti single strand (SS DNA) antibodies. Anti DS and DNA antibodies are closely related with SLE and rise and fall with the activity of the disease, and the titer of the disease is more or less negative even if...
Role of salivary anti-SSA/B antibodies for diagnosing primary Sjgren's syndrome The prevalence of rheumatoid factor and antinuclear factor were significantly higher in salivary SSB-positive pSS patients than in SSB-negative patients (p<0.05). Conclusions: Compared to parotid saliva, whole saliva is...
Serologic and clinical features of patients with discoid lupus erythematosus: Relationship of antibodies to single-stranded deoxyribonucleic acid and of other antinuclear antibody subsets to clinical manifestations Callen JP,Fowler JF,Kulick KB (1985) Serologic and clinical features of patients with discoid...
The aim of this study is to evaluate the relationship between antinuclear antibody (ANA) titer and specificity, as well as the relationship between the number of positive-autoantibodies (AAbs) in antinuclear antibodies (ANAs) and specificity for systemic
ObjectiveThe expression of antinuclear antibodies (ANA) is considered almost constant in systemic lupus erythematosus (SLE), although recent experience has suggested that many subjects with SLE considered for clinical trials are ANA negative at screening. The objective of this study is to determine ...
Nine (4.3%) false-positive and 14 (6.7%) false-negative results were detected. Of these, 13 (93%) represented no risk for the diagnosis and therapeutic management of the patients. The CLIA methodology reduced the need for the IFA manual technique by 77% (160/209). The ANA screening ...
Objective In the development of new therapies for systemic lupus erythematosus (SLE), positivity for antinuclear antibodies (ANAs) represents a criterion for trial eligibility. Since as many as 30% of patients in trials have been ANA negative, we evaluated the performance characteristics of ...