ARDB—antibiotic resistance genes database. Nucleic Acids Res 37, D443–D447 (2009). ARDB was one of the first general antimicrobial resistance gene databases, and this paper spawned several other efforts to compile resistance gene information across drug classes and bacterial species. Article CAS ...
Using the eggNOG database, we found that a high number of bacterial reads (2.6%) were assigned to defence mechanism function. The majority of those proteins (25.5%) were annotated as part of an ABC-transport system. More specific profiling of antimicrobial resistance genes in the metagenomic ...
There were 2472 sequences were obtained from the ResFinder database (version 3.2, November, 2016)32, associated with 67 antibiotic resistance families. ResFinder was selected on account of its manual curation of genes associated with acquired antibiotic resistance. An additional 409 ARG-associated ...
Forty isolates (44.4%) possessed multiple antimicrobial resistance to at least three antimicrobials. The V. parahaemolyticus population was composed of 68 sequence types, of which 41 were novel to the pubMLST database, displaying a high level of genetic diversity. The phylogenetic relatedness of V....
The dust resistome was characterized by identifying antibiotic resistance genes annotated in the Comprehensive Antibiotic Resistance Database (CARD) from the metagenomes of each sample using the Short, Better Representative Extract Data set (ShortBRED). The three most highly abundant antibiotic resistance ...
Acquired resistance genes enable the bacterium to produce enzymes that destroy the antibacterial drug, to express efflux systems that pump the antimicrobial agents out of the cell before reaching their intracellular target, to modify the antimicrobial agent's target site, or to produce an alternative ...
WGS is a molecular typing method that can be used to identify specific AMR genes in the genome of a bacterium. WGS produces a nearly complete DNA sequence of the bacteria which can then be compared to a database containing sequences of known genes of interest to identify their presence in ...
et al. Phylogenetic barriers to horizontal transfer of antimicrobial peptide resistance genes in the human gut microbiota. Nat. Microbiol. 4, 447–458 (2019). CAS PubMed Google Scholar Swidergall, M. & Ernst, J. F. Interplay between candida albicans and the antimicrobial peptide armory. ...
In 2015, the World Health Organization (WHO) launched a Global Antimicrobial Resistance and Use Surveillance System (GLASS), which collected, evaluated, and integrated data on AMR in humans across countries and territories. In addition, the Global Health Security Index (GHS Index), the first compr...
Antimicrobial resistance quantification Trimmed reads of all libraries were aligned with KMA (v. 1.2.17a) to the ResFinder database of known and acquired resistance genes (Commit 813679d) and the Silva (Silva version 138) database made from more than 13 million sequences 16/18 S rRNA, whi...