To enable accurate assessment of AMR gene content, as part of a multi-agency collaboration, NCBI developed a comprehensive AMR gene database, the Bacterial Antimicrobial Resistance Reference Gene Database and the AMR gene detection tool AMRFinder. Here, we describe the expansion of the Reference ...
Antimicrobial resistance (AMR) is an intensifying threat that requires urgent mitigation to avoid a post-antibiotic era.Pseudomonas aeruginosarepresents one of the greatest AMR concerns due to increasing multi- and pan-drug resistance rates. Shotgun sequencing is gaining traction for in silico AMR prof...
To enable accurate assessment of AMR gene content, as part of a multi-agency collaboration, NCBI developed a comprehensive AMR gene database, the Bacterial Antimicrobial Resistance Reference Gene Database and the AMR gene detection tool AMRFinder. Here, we describe the expansion of the Reference ...
Identification of pathogenic bacteria from clinical specimens and evaluating their antimicrobial resistance (AMR) are laborious tasks that involve in vitro cultivation, isolation, and susceptibility testing. Recently, a number of methods have been developed that use machine learning algorithms applied to the...
Antimicrobial resistance (AMR) is a major threat to human health worldwide, and the rapid detection and quantification of resistance, combined with antimicrobial stewardship, are key interventions to combat the spread and emergence of AMR. Antimicrobial susceptibility testing (AST) systems are the colle...
The high priority given to antimicrobial resistance (AMR) has led to the European Commission action plan against the rising threat of AMR [1] and the World Health Organization Global strategy for the containment of AMR [2]. Emergence and spread of AMR has usually been attributed ...
In-silico detection of AMR genes and virulence-associated determinants was performed by using different databases, i.e. the Resistance Gene Identifier (RGI) based on the Comprehensive Antibiotic Resistance Database (CARD) [26], the ResFinder database [27], and the NCBI AMR Finder Plus (https:...
FASTA file of nucleotide sequences, saytinyamr.fa. Ideally the sequence IDs would have the format>DB~~~ID~~~ACC~~~RESISTANCES DESCwhereDBistinyamr,IDis the gene name,ACCis an accession number of the sequence source,RESISTANCESis the phenotype(s) to report, andDESCcan be any textual ...
Bloodstream infections caused by the opportunistic pathogen Klebsiella pneumoniae are associated with adverse health complications and high mortality rates. Antimicrobial resistance (AMR) limits available treatment options, thus exacerbating its public h
Antibiotic/antimicrobial resistance (AR/AMR): biggest threats and data. CDC http://www.cdc.gov/drugresistance/threat-report-2013/ (updated 26 Nov 2018). Smith, R. & Coast, J. The true cost of antimicrobial resistance. BMJ 346, f1493 (2013). Article PubMed Google Scholar O’Neill, J...