Recently, anti-infective properties of Aβ peptides have been reported. Here, we investigated the interaction of Aβ peptides of different lengths with various bacterial strains and the yeastCandida albicans. The amyloidogenic peptides Aβ1-42, Aβ2-42, and Aβ3p-42but not the non-amyloid...
L. et al. Antimicrobial properties of amyloid peptides. Mol Pharm 9, 708–717, doi: 10.1021/mp200419b (2012). 16. Soscia, S. J. et al. The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide. PLoS One 5, e9505, doi: 10.1371/journal.pone.0009505 (2010)....
The target specificity, killing efficacy, mode of action, and biochemical properties vary between the peptides. In addition to their antimicrobial activity they can also act as mediators of the adaptive immune system [9] and other cellular processes like wound healing [10]. Most of the peptides...
Experimental evolution of resistance to an antimicrobial peptide A novel class of antibiotics based on the antimicrobial properties of immune peptides of multicellular organisms is attracting increasing interest as a maj... GG Perron,M Zasloff,G Bell - 《Proceedings of the Royal Society B Biological...
Interestingly, the antimicrobial properties of human hepcidins are enhanced at acidic pH, rendering these peptides appealing for the design of new drugs targeting infections that occur in body areas with acidic physiological pH. This review not only considers current research on the direct killing ...
Antimicrobial peptides (AMPs) play an important role as a host defense against microbial pathogens and are key components of the human innate immune response. Neisseria meningitidis frequently colonizes the human nasopharynx as a commensal but also is a worldwide cause of epidemic meningitis and rapid...
BC Monk,K Niimi,S Lin,... - 《Antimicrobial Agents & Chemotherapy》 被引量: 106发表: 2005年 Direct comparison of membrane interactions of model peptides composed of only Leu and Lys residues We compared the properties of two peptides of identical size and amino acid composition, Ac-(LKKL...
Chemical structure and self-assembly properties of AMPs.AThe molecular structure of peptides is designed as hydrophobic modules, hydrogen bond modules and antimicrobial peptide modules.BAmino acid composition of the designed peptides.CDiagram of the transition mode from nanoparticles to nanofibers.DThe ...
Vmh2 hydrophobin as a tool for the development of "self‐immobilizing" enzymes for biosensing Self‐assembling proteins forming amyloid fibrils are promising candidates for the fabrication of biomaterials, due to the chemical and mechanical stabilit... A Piscitelli,A Pennacchio,S Longobardi,... - 《...
The multiple properties of AMP make them optimistic and powerful candidates to replace conventional drugs. Moreover, the development of new natural peptide-based antimicrobials for livestock, swine and poultry can help to reduce the antimicrobial problem without affecting either animal production or human...