Currently, multiple AMPs are assessed in late-stage clinical trials, not only as novel anti-infective drugs, but also as innovative product candidates for immunomodulation, promotion of wound healing, and prevention of post-operative scars. The efforts to translate AMP-based research findings into ...
“susceptible-dose dependent (SDD) – a category defined by a breakpoint that implies that susceptibility of an isolate depends on the dosing regimen that is used in the patient. To achieve levels that are likely to be clinically effective against isolates for which the susceptibility testing resu...
A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs. Curr. Eye Res. 2005, 30, 505–515. [Google Scholar] [CrossRef] [PubMed] Mahlapuu, M.; Håkansson, J.; Ringstad, L.; Björn, C. Antimicrobial peptides: An emerging category of therapeutic ...
quinolones (27%), tetracyclines (20%), amphenicols (18%), and sulfonamides (14%). Antimicrobials listed by the World Health Organization (WHO) as critically important and highly important for human medicine39accounted for 35% and 61% of use, respectively, across surveys (Supplementary Fig.S4)...
albicans[115,121]. Some cecropins also show anti-inflammatory activity [122,123]. Inflammation is a protective response of a tissue triggered by pathogen infection and involved in the reparative processes [124]. In Table2, the major insect cecropins with reported antimicrobial activity are listed...
Azole compounds, particularly fluconazole, are the most commonly used antifungals because they are highly advantageous over other antifungal drugs in terms of cost, safety, oral bioavailability, and the ability to cross the blood–brain barrier. Unfortunately, the repeated use of fluconazole for the ...
”Responses were categorised as accurate, partly accurate or inaccurate, according to the World Health Organisation (WHO 2017) and the O'Neill Commission's (O'Neill, 2014) definitions: 'When a microorganism changes when exposed to antimicrobial drugs, resulting in the medicines becoming ineffective...
For example, the scope of a fund could be defined as ‘advanced pharmaceutical and biotechnology technologies’ or, in more detail, as focusing on a specific disease or category of disease, such as ‘new oncology drugs’. Setting GGFs’ investment stage. As discussed above, the stage at ...
Before this change, the I category was used in two very different scenarios. First, when a level of antimicrobial activity was associated with uncertain therapeutic effect. This implies that an infection due to the isolate may be appropriately treated in body sites where the drugs are ...
Updated panels that include more antipseudomonal drugs could be utilised to determine their MDR status in the future. Pseudomonas aeruginosa had a low susceptibility to the antipseudomonal penicillin + ß-lactamase inhibitor TZP of 20% however, only a few isolates (n = 5) were ...