Symptom severity, as recorded by the visual analogue scales, was not significantly different for sneezing, rhinorrhoea, blocked nose or overall between the two groups but the symptom scores for itchy eyes were significantly better for the astemizole group. Adverse effects were minimal and...
There were 44 subjects randomized to each arm of the study, and, because randomization was blocked in groups of 4, the number of subjects enrolled at any point was divided equally between intranasal corticosteroid and H1 receptor antagonist treatments. The groups were matched for ag...
since the acid controls the local bacterial population. In the 1970s a new class of synthetic drugs was invented that blocked the action of histamine at its H2receptors; the first of these agents wascimetidine(Tagamet). These drugs were shown to be extremely effective in antagonizing the action...