These lymphoid cells can be used to provide antigen-specific T-cell receptors with predetermined MHC restriction and to identify immunically meaningful T cell epitopes. A nucleic acid encoding a T-cell receptor that specifically binds to an epitope of a transmembrane membrane phosphatase (TpTe) ...
Engager T Cells: A New Class of Antigen-specific T Cells That Redirect Bystander T CellsAdoptive immunotherapy with antigen-specific T cells has shown promise for the treatment of malignancies. However, infused T cells are unable to redirect resident T cells, limiting potential benefit. While the...
Detection of more than 1,000 different T-cell specificities in parallel facilitates identification of cancer and autoimmune antigens. Identification of the peptides recognized by individual T cells is important for understanding and treating immune-relat
T cells from lymph nodes draining the sites of immunization were prepared as previously described (23) by passage over nylon-wool columns and cultured in Click's medium with 100 #g/ml of antigen and irradiated (2,000 rad) spleen cells as a source of antigen- presenting cells.Soft Agar ...
CD4+T数量减少及功能异常是艾滋病发病的主要机制,而艾滋患者对结核病高度易感,证明了CD4+T细胞免疫在抗结核免疫中的关键作用。CD4基因缺陷小鼠虽然在结核分枝杆菌感染早期抵抗力显著降低,但中后期抗结核免疫力与正常小鼠相似,提示CD8+T细胞在结核免疫保护中也发挥了非常重要的作用。为了研究结核抗原特异性T细胞免疫应答...
Antigen-specific CD4(+) T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling. Nagaraj S,Nelson A,Youn JI,et al.Antigen-Specific CD4+T Cells Regulate Function of Myeloid-Derived Suppressor Cells in Cancer via Retrograde MHC ClassⅡ... Sri...
Adoptive immunotherapy with antigen-specific T cells has shown promise for the treatment of malignancies. However, infused T cells are unable to redirect resident T cells, limiting potential benefit. While the infusion of bispecific T-cell engagers can redirect resident T cells to tumors, these mol...
ahe tried to quit,but he couldn't.he still worries about everying 他设法放弃,但他不可能.he仍然担心everying[translate] a例如:“他请了两个星期的假,在家养病。”这句话中的“养病”并不是像“养猫”、“养狗”一样,把病养起来的意思,而是休养、治病的意思。 正在翻译,请等待...[translate] ...
(2015) Engager T Cells: A New Class of Antigen-specific T Cells That Redirect Bystander T Cells. Molecular Therapy 23 , 171-178 /... Y Yamamoto,K Iwahori,S Funaki,... - 《Scientific Reports》 被引量: 0发表: 2020年 Interim results of an ongoing phase 1/2a study of HPN328, a tri...
However, at the peak of the response, greater numbers of DO11.10 T cells were found in the aged hosts. Regardless of the age of the host, the donor DO11.10 T cell population differentiated into functional effector cells. Despite the increased CD4 T cell growth in aged hosts, similar ...