Antigen-specific human antibodies from mice comprising four distinct genetic modifications. Nature 1994, 368, 856-859. [CrossRef] [PubMed]Lonberg N, Taylor LD, Harding FA, Trounstine M, Higgins KM, Schramm SR et al (1994) Antigen-specific human antibodies from mice comprising four distinct ...
Here we have designed a novel class of engineered antibody-based reagents (‘Seldegs’) that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, myeli
Further, a method of treating a disease or disorder caused by a known antigen in an individual in need of an increased number of antigen-specific antibodies is disclosed. In the method a tailor-made antigen/antibody specificity exchanger of the invention is issued. Said method may be e.g. ...
Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning Abstract 治疗性抗体的优化是费时和消耗资源的,这主要是因为针对在哺乳动物中表达的全长抗体进行筛选是低通量的(大约103个变体),这通常导致数量很少的先导物。在这里,我们展示了通过深度学习从大量不同的...
Fig. 4 | Neural-network-predicted sequences are experimentally validated to be antigen-specific Fig5是对抗体的进一步优化,通过计算抗体Fv电荷和FvCSP、CamSOl、NetMHCIIpan分别预测抗体的黏度、可溶性、免疫原性信息,筛选高于曲妥珠单抗的抗体序列,又因为实验验证的训练集中只有9个符合条件,就将筛过的数据选取了大...
To support the development of SARS-CoV-2 diagnostic tools, ACROBiosystems supply a collection of high-quality mutants-specific antigens and antibody reagents with verified high purity, bioactivity and batch-to-batch consistency. Reagents for Antigen Test The matched SARS-CoV-2 S/N antibody pairs...
Reducing and non-reducing SDS PAGE (NuPAGE 4 to 12%, Bis-Tris gels) was performed together with immunoblotting and probing with anti-Env specific antibodies (5F3, 447–52D, 2G12). GMP-produced preparations were routinely monitored for the presence of particulate contaminants, pH, endotoxin ...
Noun1.prostate specific antigen- a protein manufactured exclusively by the prostate gland; PSA is produced for the ejaculate where it liquifies the semen and allows sperm cells to swim freely; elevated levels of PSA in blood serum are associated with benign prostatic hyperplasia and prostate cancer...
Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. The present study examines the ability of hapten-specific murine splenic B lymphocytes to present hapten-proteins to carrier-specific T cell hybridomas. BA... KL Rock,B Benacerraf,AK Abbas - 《Jou...
Here, we report efficient detection and collection of cancer cells in blood samples by combining stem cell antigen (CD44)-specific immunosilica particles and immunofluorescent quantum dots with spectrally and temporally resolved single-photon counting. We accurately detect 1–10 cells among 100 cancer ...