回复@黄建平: 其中一个原因,Fab介导的内化,antigen sink 差异//@黄建平:回复@万川印月之滇西:什么原因呢? 引用:2024-09-26 13:25 抗体的学问还挺深,比如同一个靶点,相同的Fc修饰,有的半衰期只有25天左右,有的能做到70天以上。说到底,科学界对蛋白的理解还处于初级阶段,如果了解足够深,可能就不需要筛,而是...
This chapter presents comments on the broad spectrum of autoantigens and the function of self-reactive T and B cells. The term antigen sink was used to describe the idea that antibodies are formed regularly to self constituents but are taken up by the respective antigens as rapidly as they ...
When 3min has elapsed, turn off the hotplate and place the pressure cooker in an empty sink. Activate the pressure release valve (see the manufacturer’s instructions) and run cold water over the cooker. 7. Once depressurized, open the lid and run cold water into the cooker for 10min. ...
1f), and a genetically encoded calcium indicator (GECI) to monitor intracellular calcium release43 as a marker of TCR triggering/early T-cell activation. GECI levels were kept low to prevent it behaving as a calcium sink44. We refer to this as the ‘J8-GECI’ cell line....
升級需要所有叢集相關的資訊才能繼續。首先,它會讓 Exchange 系統服務員資源離線,這將會停止所有 Antigen 服務/處理程序。它也會停止 IIS 系統管理服務,以便升級 AntigenSmtpSinkEx.dll。 5. 升級也會將 Antigen 事件資料庫、所有隔離資訊、Antigen adb 檔案以及記錄檔,從本機磁碟機複製到共用磁碟機資訊指定的共用磁碟...
By taking advantage of monoclonal antibodies generated from gut plasma cells of DH patients, we here demonstrate that BCR-bound TG3 can serve as a sink for gluten peptides and thereby facilitates crosstalk between TG3-specific B cells and gluten-specific CD4+ T cells. A similar hapten-carrier...
Sinkora M, Bilej M, Tučková L, Romanovsky A (1993) Hemolytic function of opsonizing protein of earthworm’s coelomic fluid. Cell Biol Int 17: 935–939PubMed Soderhall K, Smith VJ (1986) The prophenoloxidase activating system: the biochemistry of its activation and role in arthropod ce...
5. When 3 min have elapsed, turn off the hotplate and place the pressure cooker in an empty sink. 6. Activate the pressure release valve (see the manufacturer’s instructions) and run cold water over the cooker. Once de-pressurized, open the lid and run cold water into the cooker ...
Greiner A, Neumann M, Stingl S, Wassink S, Marx A, Riechert F,et al. Characterization of Wue-1, a novel monoclonal antibody that stimulates the growth of plasmacytoma cell lines.Virchows Arch2000;437: 372–379. ArticleCASGoogle Scholar ...
sustained decrease (>50%) in serum κFLC. MDX-1097 PK analysis revealed that MDX-1097 mAb clearance increased with increasing dose, suggesting that there was cell-associated antigen clearance (Supplementary Table2). The MDX-1097 PK profile did not fit the typical “antigen-mediated sink” ...