2005. Viral interference with MHC class I antigen presentation pathway: the battle continues. Vet. Immunol. Immunopathol. 107 1-15.Ambagala AP, Solheim JC, Srikumaran S 2005. Viral interference with MHC class I antigen presentation pathway: the battle continues . Vet Immunol Immunopathol 107 :...
This correlates with reduced IFN-I production, reduced activation of DCs, inhibition of cross-presentation, and failure to induce immunoproteasome activation, which results in the complete abrogation of the immunodominant Env294–302-specific CD8 T cell response. Together, these factors result in ...
Transcriptional regulation of the MHC class II antigen presentation pathway. Curr. Opin. Immunol. 15: 105-111.Boss, J. M., and P. E. Jensen. 2003. Transcriptional regulation of the MHC class II antigen presentation pathway. Curr. Opin. Immunol. 15:105....
It is now known that antigen-presenting cells (APCs) can present extracellular antigen to CD4 T cells on MHC class II molecules and to CD8 T cells on MHC class I molecules (a process known as cross-presentation), but what determines which presentation pathway the extracellular antigen is ...
antigenpresentation 抗原提呈是T细胞需要的 T细胞识别抗原的方式有别于BCR及其抗体(识别线性抗原肽、MHC限制性) 一些细胞能够摄取、加工、处理蛋白质,使其降解成小肽,并由细胞的MHC分子将肽运送到细胞表面供T细胞识别,这样的过程称为抗原提呈。 内容: 一、抗原的处理和提呈过程 二、抗原提呈细胞 一、抗原的处理和提呈...
1、Chapter 11 Antigen Presenting Cells and Antigen presentation I. APC (antigen presenting cells)Professional APCs(DCs, macrophages, B cells)Non-professional APCsII. Ags Processing and presenting pathwayMHC class I pathwayMHC class II pathwayCross presentationNon-classical antigen presentation pathwayC 2...
17AA peptides + exposure of the groove by release of CLIP peptide/MHC II complex express on the surface of APC, present to CD4+T celluptakeMIICPathway of MHC class I associated antigen presentationendogenous antigens in cytosol ? are degraded to peptides by the proteasome, ? bind MHC-I ...
The classical antigen presentation pathway consists of two monomorphic (proteasome and TAP) and one polymorphic components (MHC Class I). Viruses can escape CTL responses by mutating an epitope so that it is no longer correctly processed by the pathway. Whereas escape mutations that affect MHC bind...
1.Antigen presentationis not only a key procedure in immune response but also a complicated interaction and cross-talk between molecules and cells.抗原提呈是免疫应答过程中的核心环节,也是一个非常复杂的分子间相互作用的过程。 2.MethodsAntigen presentationcapability of different cells were measured by mix...
Explore the antigen processing and presentation by MHCs signaling pathway and find antibodies to detect some of its target proteins, including CD74, MHC Class I (H-2Dd), MHC Class I (H-2Dk), and MHC Class I (H-2Kd).