blood-brain barrier CD148 HPTP-eta, M4, M56 240-260kD mRNA: broad, high in brain, kidney tyrosine phosphatase R Type III CD150 SLAM, IPO-3 75kD IgSF T, B, maintained on Th1 costimulation, proliferation, Ig production CD151 PETA-3, SFA-1 32kD TM4SF endothelial, megakaryocytes, plate...
The bar chart illustrates the prevalence (%) of the F, C, and F/C alleles across different age groups. The F-allele consistently shows the highest prevalence across all groups, peaking at 70% in the 0–5 years age group and remaining above 50% in all other groups. The C-allele exhibi...
Full size image We then asked whether DCPs could generate cDC1 in mice. We used BM cells of CD45.1 mice to produce DCPs as described above, or moDCs and mature cDC1-like cells (Extended Data Fig.1c) using established protocols7,14,15. We inoculated each DC type intravenously (two dos...
A, the outer rim of the pie chart displays the percentage occupation of the HLA ligandome, and the number within each pie segment is the number of unique peptides in that segment. Of the total number of 6500 identified peptides, the top five abundant proteins occupy 6% of all HLA ...
Outline of single-cell sequencing applied to interrogate CAR-T cell biology in preclinical studies. Single-cell sequencing has been applied to interrogate CAR-T cell biology with in vitro and in vivo preclinical studies.aTo discover promising TSAs;bTo chart where the CAR-T vector integrates into ...
The bar chart (bottom) shows a compilation of the MFI values for the kappa/lambda stainings displayed in the top panel. (h) Enriched polyclonal BM plasma cells from na¨ıve mice were stimulated ex vivo with anti-IgM or anti-Igs F(ab')2 Abs and stained with anti-IgM, IgA, IgG1 ...
A substance that stimulates the production of an antibody when introduced into the body. Antigens include toxins, bacteria, viruses, and other foreign substances. See Note atblood type. The American Heritage® Student Science Dictionary, Second Edition. Copyright © 2014 by Houghton Mifflin Harcou...
Mouse leukocyte antigen distribution chart AntigenT cellB cellDendritic cellNK cellMonocyteGranulocyteMegakaryocyteErythrocyteEndothelial cell CD1d (CD1.1, Ly-38) Most Most Most Most Most Most Unkn Unkn Unkn CD2 (LFA-2) Most/Dev Sub/Dev Unkn Most Sub Most Unkn Most Unkn CD3 molecular complex Most...
Of note, we found that macrophages and DCs from cancer patients expressed a higher amount of VSIG4 than their counterparts from peripheral blood mononuclear cells of healthy donors (Fig. 1A). Macrophages and DCs derived from the bone marrow of wild-type mice showed low proportion of VSIG4 ...
‘off-the-shelf’, third-party approach to CAR-based cell therapy56,57,58,59. CAR-transduced cord blood-derived NK cells have been reported to have potent anticancer effects in preclinical studies60. This allogeneic NK cell approach to CAR cell therapy might also be associated with a reduced...