Terconazole is a topical and broad spectrum triazole antifungal agent with structural similarities to ketoconazoleWeisberg (1989). It is available for adults as a vaginal cream (2 dosages available) or as a vaginal suppository. It is approved for use in vulvovaginal candidiasis caused by Candida...
.72 According to (Endo et al, 2020) Ketoconazole-PLA, the characterization and improvement of the antifungal activity in vitro against Candida and dermatophytes shows that nanoparticles containing ketoconazole exhibited superior antifungal activity against all tested fungal strains than free ketoconazole....
Liposomal gels containing different drug:lipid ratios were prepared by proliposome approach and studied for skin permeation and skin deposition of ketoconazole. Higher ketoconazole deposition in skin with more lipid content of liposomal gel compared to marketed conventional non-liposomal cream implies ...
-> oral lozenge and topical cream -> alternation of cell membrane -permeability -> action against Candida species -> adverse reaction involves the GI tract; produce elevated liver enzyme Imidazole [Ketoconazole] -> alters cellular membranes and interferes with intracellular enzymes. ...
(fluconazole, itraconazole, ketoconazole, miconazole, clotrimazole, terbinafine and griseofulvin) were evaluated by broth micro- dilution method as proposed by the Clinical and Laboratory Standards Institute (CLSI), against 70 dermatophyte isolates from hair, skin and nail specimens of patients with ...
Abstract Dermatophytoses are fungal infections of the skin, hair, and nails that affect approximately 25% of the global population. Occlusive clothing, living in a hot humid environment, poor hygiene, proximity to animals, and crowded living conditions are important risk factors. Dermatophyte infec...
The following are representative examples of some antifungals that can be employed in the composition of the invention: amphotericin B, flucytosine, fluconazole, griseofulvin, miconazole nitrate, terbinafine hydrochloride, ketoconazole, itraconazole, undecylenic acid and chloroxylenol, ciclopirox, clotrimazole,...
A preliminary clinical trial was conducted comparing the composition of Example 8, twice daily, and a standard anhydrous cream containing 2% sertaconazole mononitrate as the only active ingredient, twice daily, in cutaneous candidiasis. The standard anhydrous cream was prepared for this experiment. Twe...
“cell wall active compound”, as used herein, means any compound which interferes with the fungal cell wall. Appropriate antifungal compounds for use in combination with the present compounds include, but are not limited to, known azoles such as fluconazole, voriconazole, itraconazole, ketoconazole,...
they play an important role in adjusting the physicochemical properties of the whole molecule to avoid some dissatisfying side effects and/or improve their pharmacokinetic and pharmacodynamic behavior. The side chains of itraconazole, ketoconazole, pramiconazole, and posaconazole are too long to be accomm...