Human poisoning by antifreeze mixture has been known for many years and its formula, HOC H2-CH20H, occupies a position between ethyl alcohol and glycerol. Mostly it has been drunk by mistake, but sometimes it has been ingested as a substitute for alcohol (Ross, 1956). The minimum lethal ...
Further increasing the importance of early recognition and treatment in cases of exposure is the fact that the preferred treatment and antidote for ethylene glycol poisoning — a compound called Fomepizole (a.k.a. 4-MP or Antizol-Vet) — at the request of the manufacturer,FDA approval for this...
Human poisoning by antifreeze mixture has been known for many years and its formula, HOC H2-CH20H, occupies a position between ethyl alcohol and glycerol. Mostly it has been drunk by mistake, but sometimes it has been ingested as a subst... M. Ahmed - 《British Journal of Ophthalmology》...
Treatment consists of blocking the formation of toxic metabolites using inhibitors of alcohol dehydrogenase, such as Antizol, and correction of metabolic abnormalities. In patients with high ethylene glycol or methanol concentrations (≥ 50 mg/dL), significant metabolic acidosis, or renal failure, hemo...
Stage 2: This occurs 12-24 hours after a dog or cat has gotten into antifreeze, and signs of “alcohol” poisoning appear to resolve, when underlying severe internal damage is still occurring. Signs of drunkenness seem to improve, but signs of an elevated heart rate, increase breathing effort...
Ethylene glycol poisoning is treated by giving 4-methylpyrazole, an antidote which inhibits alcohol dehydrogenase. Household products, such as sink cleaners, dishwashing detergents, and toilet cleaners, are also common causes of poisonings in small animals. The majority of cleaning detergents are ...
Adverse drug events associated with the antidotes for toxic alcohol poisoning : a comparison of ethanol and fomepizole Background: The toxic alcohols methanol and ethylene glycol (antifreeze) can cause severemorbidity or death if ingested. Two antidotes are available for tr... KJ Lepik 被引量: 0...
the antifreeze becomes contaminated with heavy metals, fuel and other grit from the engine. These include lead, tin, copper, zinc, iron and benzene -- some toxic in their own right. These substances, carried and deposited by antifreeze, can contaminate soil and water, poisoning organisms and ...
Its disadvantage is easy to ignite , alcohol boiling point is low, evaporation losses. After the evaporation of the alcohol , antifreeze composition changes , the freezing point increases. In the mountains, the plateau region moving car should not use alcohol - water, antifreeze , because of the...
Antifreeze poisoning: diagnosis, treatment options Ethylene glycol, the main component of antifreeze and summertime engine coolants, is the number 1 cause of poisoning deaths among dogs in the US. It is est... FW Oehme - Veterinary Medical Forum 被引量: 0发表: 2000年 ...